Detailed information of TA system TA228374

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 207738..207918
• Replicon: chromosome
• Accession: NZ_CP089586
• Organism: Staphylococcus aureus strain E1185_IV_ST12

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: LUU82_RS01355
• Protein ID: WP_001801861.1
• Coordinates: 207823..207918 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	207738..207795 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUU82_RS01325	204089..205207	+	1119	WP_000072558.1	restriction endonuclease subunit S	-
LUU82_RS01330	205855..206298	+	444	WP_000742594.1	DUF1433 domain-containing protein	-
LUU82_RS01335	206577..206855	+	279	WP_001798632.1	DUF1433 domain-containing protein	-
LUU82_RS01340	206877..207251	+	375	WP_000695818.1	DUF1433 domain-containing protein	-
LUU82_RS01345	207439..207621	+	183	Protein_230	transposase	-
LUU82_RS01350	207599..207700	-	102	WP_001791232.1	hypothetical protein	-
-	207738..207795	+	58	-	-	Antitoxin
LUU82_RS01355	207823..207918	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
LUU82_RS01360	208369..208815	+	447	WP_000747802.1	DUF1433 domain-containing protein	-
LUU82_RS01365	209500..209883	+	384	WP_000070811.1	hypothetical protein	-
LUU82_RS01370	209894..210070	+	177	WP_000375476.1	hypothetical protein	-
LUU82_RS01375	210370..210998	+	629	Protein_236	ImmA/IrrE family metallo-endopeptidase	-
LUU82_RS01380	211196..211768	-	573	WP_000414212.1	hypothetical protein	-
LUU82_RS01385	211869..212210	-	342	WP_000627548.1	DUF3969 family protein	-
LUU82_RS01390	212251..212877	-	627	WP_000669019.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	186049..215437	29388

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T228374 WP_001801861.1 NZ_CP089586:c207918-207823 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T228374 NZ_CP123897:619823-620224 [Methylomonas sp. UP202]
ATGCTGAAATATCTGCTCGACACCAACATCGTCATCTATGTGATTAAGCGGCGACCGATCGAGGTGTTGGCGACCTTCAA
CCGGCATCACGGCCGCATGGCGATTTCCGCCGTGACCCTGGCCGAATTAATCCACGGTGCCGAGAAAAGCCAATTTCCCG
AGCGAAATCTTGCCACGGTAGAAGACTTTTGCAGCCGTTTACAGGTATTGCCTTACAACGACAGCGCCGCGATGCATTAC
GGCGGCATACGCGCCGCGTTGGAGAAGATCGGCCAGCCGATAGGCGTCAACGACCTGCATATCGCCGCTCATGCCCGCAG
CCATGGCTTGATACTGGTCAGCAACAACTTGCGGGAGTTCGAACGCGTGCCGGGGTTATTGATGGAGAATTGGTTGGAGT
GA

Antitoxin

Nucleotide

• Length: 58 bp

>AT228374 NZ_CP089586:207738-207795 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin