Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1262670..1263262 Replicon chromosome
Accession NZ_CP089532
Organism Pseudomonas veronii strain G2

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag LUW10_RS05640 Protein ID WP_232591301.1
Coordinates 1262670..1262948 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LUW10_RS05645 Protein ID WP_232591856.1
Coordinates 1262957..1263262 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUW10_RS05620 (LUW10_05620) 1259034..1260182 - 1149 WP_232591299.1 OpgC domain-containing protein -
LUW10_RS05625 (LUW10_05625) 1260214..1260393 + 180 WP_232591300.1 hypothetical protein -
LUW10_RS05630 (LUW10_05630) 1260450..1260734 - 285 WP_017844581.1 putative quinol monooxygenase -
LUW10_RS05635 (LUW10_05635) 1260747..1262366 - 1620 WP_017844582.1 FMN-binding glutamate synthase family protein -
LUW10_RS05640 (LUW10_05640) 1262670..1262948 + 279 WP_232591301.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LUW10_RS05645 (LUW10_05645) 1262957..1263262 + 306 WP_232591856.1 HigA family addiction module antitoxin Antitoxin
LUW10_RS05650 (LUW10_05650) 1263343..1264734 - 1392 WP_232591302.1 ATP-binding protein -
LUW10_RS05655 (LUW10_05655) 1264731..1266545 - 1815 WP_104903844.1 ATP-binding protein -
LUW10_RS05660 (LUW10_05660) 1266556..1267461 - 906 WP_232591857.1 cytochrome c peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(11-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10450.94 Da        Isoelectric Point: 7.2151

>T228359 WP_232591301.1 NZ_CP089532:1262670-1262948 [Pseudomonas veronii]
MIRSFKCAEPPKLFETGRTRRCSAVVSVVERQLSMLDAAVELADLRSPPGNRLEPLYGDREGQHSIRINGQFRVCFIWGP
HGPENVEIVDYH

Download         Length: 279 bp

>T228359 NZ_CP123852:2304335-2304577 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAGACATTTATAGAAATTGTTGAGACTTT
AAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATTTAGAGCGATATTCAAGAAGAATTA
ACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATACTATCGGCATGGTCACATTATGAT
TAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11143.99 Da        Isoelectric Point: 7.2767

>AT228359 WP_232591856.1 NZ_CP089532:1262957-1263262 [Pseudomonas veronii]
MFKNGMRPVHPGEILKEEYLEPLGLTAAALARALHVSAPTVNDIVLMRRSISADVALRLAVALETSAQFWLNLQTAYDLR
TAEIAKGAQIYKEVERVVHCA

Download         Length: 306 bp

>AT228359 NZ_CP123852:2304078-2304335 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References