Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HTH_XRE |
Location | 1283013..1283692 | Replicon | chromosome |
Accession | NZ_CP089445 | ||
Organism | Escherichia coli strain 5-1 |
Toxin (Protein)
Gene name | higB | Uniprot ID | S1PK60 |
Locus tag | LT922_RS06155 | Protein ID | WP_000057523.1 |
Coordinates | 1283013..1283315 (+) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | S1QAY3 |
Locus tag | LT922_RS06160 | Protein ID | WP_000806442.1 |
Coordinates | 1283351..1283692 (+) | Length | 114 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LT922_RS06130 (1278389) | 1278389..1280041 | + | 1653 | WP_000771748.1 | bifunctional UDP-sugar hydrolase/5'-nucleotidase | - |
LT922_RS06135 (1280079) | 1280079..1280582 | - | 504 | WP_000667000.1 | hypothetical protein | - |
LT922_RS06140 (1280579) | 1280579..1281235 | - | 657 | WP_015674862.1 | hypothetical protein | - |
LT922_RS06145 (1281403) | 1281403..1281882 | - | 480 | WP_000186633.1 | Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK | - |
LT922_RS06150 (1282086) | 1282086..1282880 | - | 795 | WP_000365147.1 | TraB/GumN family protein | - |
LT922_RS06155 (1283013) | 1283013..1283315 | + | 303 | WP_000057523.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
LT922_RS06160 (1283351) | 1283351..1283692 | + | 342 | WP_000806442.1 | HigA family addiction module antitoxin | Antitoxin |
LT922_RS06165 (1283750) | 1283750..1286254 | - | 2505 | WP_000083947.1 | copper-exporting P-type ATPase CopA | - |
LT922_RS06170 (1286516) | 1286516..1287448 | + | 933 | WP_000883041.1 | glutaminase A | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11809.44 Da Isoelectric Point: 10.3980
>T228281 WP_000057523.1 NZ_CP089445:1283013-1283315 [Escherichia coli]
MAQKKNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY
MAQKKNIRSFRDAWLADFFVHSTPHRKIPAEIHTTLSRKLDIINAATSHRDLRSPPGNRYEELSGKLQEYSSIRVNKQYR
LIFKWVNGKAEELFLDPHNY
Download Length: 303 bp
>T228281 NZ_CP123618:1670049-1670339 [Pasteurella multocida]
ATGAGTAAAAAAGTAGAATTGAAGCCATTTGATATTGCTGAACATCTAGATAGTGAAGAAATGATTGCCGCATATTTAAG
TGAAGTTTTAGAAACAGGTGATACTAATGAATTTATTTCCGCGCTAGGTGATGTTGCAAGAGCAAGAGGAATGACGGAGT
TAGCAGCAAAAACAGGGTTGGGAAGAGAAAGTCTTTATAAAACATTATCATACGGTAGTAAGCCACGTTTTGATACTATA
ATGAAAATTACGCAAGCATTAGGTATTAAACTTGTCCCAACGCACATCTAA
ATGAGTAAAAAAGTAGAATTGAAGCCATTTGATATTGCTGAACATCTAGATAGTGAAGAAATGATTGCCGCATATTTAAG
TGAAGTTTTAGAAACAGGTGATACTAATGAATTTATTTCCGCGCTAGGTGATGTTGCAAGAGCAAGAGGAATGACGGAGT
TAGCAGCAAAAACAGGGTTGGGAAGAGAAAGTCTTTATAAAACATTATCATACGGTAGTAAGCCACGTTTTGATACTATA
ATGAAAATTACGCAAGCATTAGGTATTAAACTTGTCCCAACGCACATCTAA
Antitoxin
Download Length: 114 a.a. Molecular weight: 13171.10 Da Isoelectric Point: 5.7790
>AT228281 WP_000806442.1 NZ_CP089445:1283351-1283692 [Escherichia coli]
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA
MKQATRKPTTPGDILLYEYLEPLDLKINELAELLHVHRNSVSALINNNRKLTTEMAFRLAKVFDTTVDFWLNLQAAVDLW
EVENNMRTQEELGRIETVAEYLARREERAKKVA
Download Length: 342 bp
>AT228281 NZ_CP123618:1669738-1670052 [Pasteurella multocida]
ATGTTTGAGCTAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGCTAAAAGATTTGTCGGCTAAGGCGGCTATTCT
TGCTCGTATTAATAGAGCTAAAAATGGTAATTTTGGCGATCACAAATCAGTTGGTGATGGCTTGTATGAAATGAGAATAA
TGAAAGGAGCTGGTTATAGGGTTTATTACACACAATACAAAGATGTAACCTATTTGTTAATTTGCGGAGGTGATAAATCT
ACACAGAAAGCAGACATCGCTAAAGCAAAAGTTTTATGGGAAGAGATTAAGCAGAAAGAGGGGGTAAATGTATGA
ATGTTTGAGCTAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGCTAAAAGATTTGTCGGCTAAGGCGGCTATTCT
TGCTCGTATTAATAGAGCTAAAAATGGTAATTTTGGCGATCACAAATCAGTTGGTGATGGCTTGTATGAAATGAGAATAA
TGAAAGGAGCTGGTTATAGGGTTTATTACACACAATACAAAGATGTAACCTATTTGTTAATTTGCGGAGGTGATAAATCT
ACACAGAAAGCAGACATCGCTAAAGCAAAAGTTTTATGGGAAGAGATTAAGCAGAAAGAGGGGGTAAATGTATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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