Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1721817..1722477 Replicon chromosome
Accession NZ_CP089441
Organism Klebsiella quasipneumoniae strain GLW9C22

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LT990_RS08330 Protein ID WP_049092199.1
Coordinates 1722124..1722477 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LT990_RS08325 Protein ID WP_000533827.1
Coordinates 1721817..1722119 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT990_RS08300 (1717025) 1717025..1718128 - 1104 WP_087827350.1 AarF/UbiB family protein -
LT990_RS08310 (1718651) 1718651..1720087 + 1437 WP_023290315.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
LT990_RS08320 (1720451) 1720451..1721381 + 931 Protein_1620 integrase arm-type DNA-binding domain-containing protein -
LT990_RS08325 (1721817) 1721817..1722119 - 303 WP_000533827.1 XRE family transcriptional regulator Antitoxin
LT990_RS08330 (1722124) 1722124..1722477 - 354 WP_049092199.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LT990_RS08335 (1722975) 1722975..1723197 - 223 Protein_1623 helix-turn-helix transcriptional regulator -
LT990_RS08340 (1723194) 1723194..1723655 - 462 WP_087827349.1 hypothetical protein -
LT990_RS08345 (1724015) 1724015..1725625 - 1611 WP_087827348.1 LA2681 family HEPN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13456.40 Da        Isoelectric Point: 9.9199

>T228256 WP_049092199.1 NZ_CP089441:c1722477-1722124 [Klebsiella quasipneumoniae]
MWTIKTTDTFDRWFASLSDTDRVSMLAALLVLREKGPGLSRPYADTVRGSRYSNMKELRIQSRGAPIRAFFAFDPTRTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNTLKEKE

Download         Length: 354 bp

>T228256 NZ_CP123597:c4360855-4360475 [Serratia marcescens]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATTCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTTT
GACCGAATACCACACCAATCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAGCAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTATCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTACCGGCTGTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11040.81 Da        Isoelectric Point: 5.7316

>AT228256 WP_000533827.1 NZ_CP089441:c1722119-1721817 [Klebsiella quasipneumoniae]
MGRTLEQLIADEKPEVVAEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp

>AT228256 NZ_CP123597:c4361076-4360855 [Serratia marcescens]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGCTATCTGACGGAGAACCACGTTGAAGATCCCAGCAATGCTTTCGGGCTCT
GGTCCGGGGCGATGGGAGATGGCGTGGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References