Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1687762..1688274 Replicon chromosome
Accession NC_010582
Organism Streptococcus pneumoniae CGSP14

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag SPCG_RS08865 Protein ID WP_000924721.1
Coordinates 1687762..1688016 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag SPCG_RS08870 Protein ID WP_000388572.1
Coordinates 1688020..1688274 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPCG_RS08850 1684863..1685177 - 315 WP_001817694.1 DNA-directed RNA polymerase subunit omega -
SPCG_RS08855 1685202..1685828 - 627 WP_000775037.1 guanylate kinase -
SPCG_RS08860 1685958..1687571 - 1614 WP_000404940.1 ribonuclease Y -
SPCG_RS08865 1687762..1688016 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
SPCG_RS08870 1688020..1688274 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SPCG_RS08875 1688512..1689609 - 1098 WP_000156330.1 nucleotidyltransferase -
SPCG_RS08880 1689619..1690359 - 741 WP_000257072.1 class I SAM-dependent methyltransferase -
SPCG_RS08885 1690679..1691032 - 354 WP_001003001.1 ribosome silencing factor -
SPCG_RS08890 1691045..1691545 - 501 WP_000844707.1 cysteine hydrolase -
SPCG_RS08895 1691546..1692139 - 594 WP_000121651.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
SPCG_RS08900 1692139..1692768 - 630 WP_000151313.1 nicotinate-nucleotide adenylyltransferase -
SPCG_RS08905 1692820..1693131 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T22823 WP_000924721.1 NC_010582:c1688016-1687762 [Streptococcus pneumoniae CGSP14]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T22823 NC_010582:c1688016-1687762 [Streptococcus pneumoniae CGSP14]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAATCAGGATAAGAAAACGTTAAAAAGAAT
CAATAAACTAATCAAGGATATTCAACGTGATCCCTTTACAGGAATAGGTAAACCAGAACCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT22823 WP_000388572.1 NC_010582:c1688274-1688020 [Streptococcus pneumoniae CGSP14]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT22823 NC_010582:c1688274-1688020 [Streptococcus pneumoniae CGSP14]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTCCTTTCAAAGAGTGAGTGGGATAGTATCCAAGAAACCCTGA
GAATTGCTCAAAATAAGGAACTTTCTGATAAGGTTTTGCGAGGAATGGCTCAAGTTCGTGCTGGAAGTACTCAGGTCCAT
GTTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References