Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 407179..407825 Replicon chromosome
Accession NZ_CP089385
Organism Klebsiella variicola subsp. variicola strain KPN692

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LUX40_RS01850 Protein ID WP_110211111.1
Coordinates 407179..407526 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1F2LZT5
Locus tag LUX40_RS01855 Protein ID WP_008806992.1
Coordinates 407526..407825 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUX40_RS01840 (LUX40_01840) 403066..404499 + 1434 WP_004202133.1 glycogen synthase GlgA -
LUX40_RS01845 (LUX40_01845) 404517..406964 + 2448 WP_232393083.1 glycogen phosphorylase -
LUX40_RS01850 (LUX40_01850) 407179..407526 + 348 WP_110211111.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LUX40_RS01855 (LUX40_01855) 407526..407825 + 300 WP_008806992.1 XRE family transcriptional regulator Antitoxin
LUX40_RS01860 (LUX40_01860) 407888..409396 - 1509 WP_008806993.1 glycerol-3-phosphate dehydrogenase -
LUX40_RS01865 (LUX40_01865) 409601..409930 + 330 WP_004202138.1 thiosulfate sulfurtransferase GlpE -
LUX40_RS01870 (LUX40_01870) 409981..410811 + 831 WP_008806994.1 rhomboid family intramembrane serine protease GlpG -
LUX40_RS01875 (LUX40_01875) 410861..411619 + 759 WP_008806995.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13476.40 Da        Isoelectric Point: 5.6651

>T228132 WP_110211111.1 NZ_CP089385:407179-407526 [Klebsiella variicola subsp. variicola]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFGPQLGRPYVDTVKDSTFQNMKELWAQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKETITLADREFSQHLTKER

Download         Length: 348 bp

>T228132 NZ_CP123306:242677-243537 [Mycoplasmopsis bovis]
ATGAATAAAAATAAATTAATAAGTTTGTGTCATAAAACTGCTGATGAAAATAACGCAAATTTCAATGTTGTTTTAATTCA
ATATTTTATGGAAAGCATTCTACGAAGAATATCTAAAAGTAATGAGAGAGACAATTTTGTGTTCAAGGGCGGTTTTCTTT
TATCTAACATTATGGGGTTAGATAAAAGAGCTACAATGGATATTGATTTGGAGCTAATAAAAACTCAAAAGATAAGTGCT
TCTAAAATATTAGAAAAATTTAAAAGTATATTAAACGCTGATGACATCGATGGAATTAGATATCACATTCTTAAGTATAC
TGACATTCGAAAGGAGCATAAATATAGTGGCATTAACATATCAGTCCTATGTCAAATAGAGAATATAAAACAAGTTATTT
CTATAGATATTGCATCAGGCGATGTCATTACACCTAAGGAAATTGTTTATGAATACAAAAGTATATTTTCAAATCAGGAT
TTTTCTATTTTAGCTTATAACATTGAAACTATGCTATCTGAAAAGCTTGAGACAATATTTTCTTTTGGTCACTTAAATAC
AAGATTTAAAGATTTTTATGATGTTTATGTTATATACACTTTTAAAAAGAAGGACATTGATATTAATAGGCTCAAGGATG
CTTGCTATAACACATTCAAAAATAGGAACAGTGAATTTAACATACAACAATTGTTGGAACTAATTACCAATATTGCTTTC
AATCCGTTGATGAATGAAAGATGAAAAAAGTACATAAGTCAGATAGCAAATCAGCAGGAAATAGACTTTAAAGCCATTAC
TAATTCAATAATAGAACTACTAGAACTAATTAAGGTCAATGAATTAACAAATAATGATTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10814.61 Da        Isoelectric Point: 10.1464

>AT228132 WP_008806992.1 NZ_CP089385:407526-407825 [Klebsiella variicola subsp. variicola]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT228132 NZ_CP123306:242070-242684 [Mycoplasmopsis bovis]
ATGGAACAAAAAAACTTAAATTCGAAATATTACAATGCAATTTTTAAACTGTTACATAAAAATAACGGTGTTATCACATA
TAAGCAACTAAAAGAAAACAATATATCTTCTATATATTTAACAAGAATGATAACAAAAGGCGTTCTTATTAGAAGAGCTA
AAGGCATTTATATTCTTAGTGATGGACATTACGATGAATATTATTTCTTAAGCAAAAACTATAAATCGTTAATCTTTTCT
CATTATAGTGCACTATATTTAAATAATATTATTGACATTTTTCCGCATCAAATTGACGTTACAGTTTACAGTGGCTATAA
TGCAAAAGGCATTAAGAAGCATGCAAATGTTTACTACTGTGATAGGAATAAACATTCAATTGGACTATCTGAATCAAAAA
CATTATTTGGAAACAAAGTTAAGGTATATGACTTTGAGAGAACAATTTGTGATTTTGTAAAACTACGCAAGAAAACAGAT
AGCGAAATCTTTTCTAAGCTTATTAGTGCATATATTAAATATGAAAATAGAGATTGAAAAAAATTGTATGAATACGCCTA
TGAATTAGGCATACACAAAAAAATATCGGAGATATTTGAACTATTTTATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2LZT5

References