Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1155135..1155738 Replicon chromosome
Accession NZ_CP089333
Organism Eggerthella lenta strain APC055-539-5C

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag LT409_RS05100 Protein ID WP_114558063.1
Coordinates 1155135..1155416 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LT409_RS05105 Protein ID WP_226844067.1
Coordinates 1155442..1155738 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT409_RS05080 1150847..1151971 + 1125 WP_114558061.1 aldo/keto reductase -
LT409_RS05085 1151968..1152600 + 633 WP_114558060.1 7-cyano-7-deazaguanine synthase -
LT409_RS05090 1152702..1153649 + 948 WP_139912889.1 CtkA family protein -
LT409_RS05095 1153787..1155103 + 1317 WP_114558058.1 amidohydrolase family protein -
LT409_RS05100 1155135..1155416 + 282 WP_114558063.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LT409_RS05105 1155442..1155738 + 297 WP_226844067.1 HigA family addiction module antitoxin Antitoxin
LT409_RS05110 1155740..1157416 - 1677 WP_139912888.1 VWA domain-containing protein -
LT409_RS05115 1157438..1158034 - 597 WP_139912887.1 hypothetical protein -
LT409_RS05120 1158024..1158485 - 462 WP_227111478.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10506.00 Da        Isoelectric Point: 7.2921

>T228109 WP_114558063.1 NZ_CP089333:1155135-1155416 [Eggerthella lenta]
MIKTFADKDAERLFTDGSCKRISSDVAARTVRKLDMIDAALALEDLRVPPGNRLHALKGDRAGMHAISVNDQWRLCFRFE
GQHAYDVALCDYH

Download         Length: 282 bp

>T228109 NZ_CP123282:4068635-4069051 [Salmonella sp. SA14318]
ATGAGTAAAACCTACATGCTGGATACCTGCATCTGTTCTTTCATTATGCGCGAACAGCCGGAAGCTGTGCTGAAACGCCT
TGAGCAGGCAGTGCTGCGCCGCCATCGTATTGTGGTGTCGGCGATTACCTACGCCGAAATGCGTTTTGGCTGTACGGGCA
AAAAGGCCTCGCCGCGCCATGCCCAACTGGTCGATGCATTCTGTAGTCGCCTGGATGCCGTGCTGGCCTGGGACCGGGCG
GCAGTGGATGCCACCACAGAGATCCGTGCCGTACTGGCCGCCGCCGGTACGCCGATTGGATCAAACGATGCGGCTATCGC
CGGCCATGCCATTGCGTCCGGGGCGATACTGGTCACTAATAACGTGAGGGAGTTTGAGCGGGTACCGGGTTTGCAGTACG
AAGATTGGGTAAAATAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11285.01 Da        Isoelectric Point: 5.7378

>AT228109 WP_226844067.1 NZ_CP089333:1155442-1155738 [Eggerthella lenta]
MILMARKPTHPGEVLREEFMPDYGLTVASLAKRLGVSRQSVNEVVRERRAVSTEMAMRLSRLFGTSAEYWLNLQRNVDLW
ESLDLHREELDAIEALIA

Download         Length: 297 bp

>AT228109 NZ_CP123282:4068408-4068638 [Salmonella sp. SA14318]
ATGCGAACCGTATCTGTATTTAAAAATGGCAATAACCGCGCGATCCGCCTTCCACGCGATCTGGATTTTGACGGCGTCAA
CGAACTTGAAATCTTCCGCGAAGGCGACACGATTATACTGCGCCCCGCCCGCCCTTCCTGGGGATCATTCCGTCATGAGG
AAAAAGCCAGCCCAGACTTTCTGACGGAACGCGAAGACATCATCAGCGATGAGGGACGCTTTGAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References