Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 369729..370375 Replicon chromosome
Accession NZ_CP089325
Organism Klebsiella pneumoniae strain KP062

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag LUX41_RS01695 Protein ID WP_016529833.1
Coordinates 369729..370076 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag LUX41_RS01700 Protein ID WP_004174017.1
Coordinates 370076..370375 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUX41_RS01685 (365655) 365655..367088 + 1434 WP_002920564.1 glycogen synthase GlgA -
LUX41_RS01690 (367106) 367106..369553 + 2448 WP_002920561.1 glycogen phosphorylase -
LUX41_RS01695 (369729) 369729..370076 + 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LUX41_RS01700 (370076) 370076..370375 + 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
LUX41_RS01705 (370438) 370438..371946 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
LUX41_RS01710 (372151) 372151..372480 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
LUX41_RS01715 (372531) 372531..373361 + 831 WP_032428425.1 rhomboid family intramembrane serine protease GlpG -
LUX41_RS01720 (373411) 373411..374169 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T228086 WP_016529833.1 NZ_CP089325:369729-370076 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T228086 NZ_CP123280:1764118-1764336 [Salmonella sp. SA17155]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT228086 WP_004174017.1 NZ_CP089325:370076-370375 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT228086 NZ_CP123280:1763716-1764090 [Salmonella sp. SA17155]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References