Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4549399..4550153 | Replicon | chromosome |
| Accession | NZ_CP089313 | ||
| Organism | Salmonella enterica subsp. enterica serovar Indiana strain YZ21MCS4 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A4Y6MJG6 |
| Locus tag | LT987_RS22015 | Protein ID | WP_000558165.1 |
| Coordinates | 4549399..4549710 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LT987_RS22020 | Protein ID | WP_001259009.1 |
| Coordinates | 4549707..4550153 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LT987_RS21985 (4545065) | 4545065..4545967 | + | 903 | WP_051129234.1 | formate dehydrogenase subunit beta | - |
| LT987_RS21990 (4545964) | 4545964..4546599 | + | 636 | WP_000829028.1 | formate dehydrogenase cytochrome b556 subunit | - |
| LT987_RS21995 (4546596) | 4546596..4547525 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| LT987_RS22000 (4547563) | 4547563..4547937 | - | 375 | WP_000238494.1 | type II toxin-antitoxin system VapC family toxin | - |
| LT987_RS22005 (4547937) | 4547937..4548179 | - | 243 | WP_001523745.1 | CopG family transcriptional regulator | - |
| LT987_RS22010 (4548384) | 4548384..4549313 | + | 930 | WP_001162861.1 | alpha/beta hydrolase | - |
| LT987_RS22015 (4549399) | 4549399..4549710 | + | 312 | WP_000558165.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| LT987_RS22020 (4549707) | 4549707..4550153 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| LT987_RS22025 (4550168) | 4550168..4551109 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| LT987_RS22030 (4551154) | 4551154..4551591 | - | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
| LT987_RS22035 (4551588) | 4551588..4552460 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| LT987_RS22040 (4552454) | 4552454..4553053 | - | 600 | WP_023227076.1 | glucose-1-phosphatase | - |
| LT987_RS22045 (4553244) | 4553244..4554047 | - | 804 | WP_000059689.1 | DeoR family transcriptional regulator | - |
| LT987_RS22050 (4554081) | 4554081..4554977 | - | 897 | WP_023227075.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12433.34 Da Isoelectric Point: 8.4020
>T228044 WP_000558165.1 NZ_CP089313:4549399-4549710 [Salmonella enterica subsp. enterica serovar Indiana]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNEE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNEE
Download Length: 312 bp
>T228044 NZ_CP123260:3834843-3835121 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT228044 WP_001259009.1 NZ_CP089313:4549707-4550153 [Salmonella enterica subsp. enterica serovar Indiana]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT228044 NZ_CP123260:3834580-3834840 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|