Detailed information of TA system TA022803

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1377761..1378274
• Replicon: chromosome
• Accession: NC_010556
• Organism: Exiguobacterium sibiricum 255-15

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: EXIG_RS07130
• Protein ID: WP_041261583.1
• Coordinates: 1378008..1378274 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: B1YFG3
• Locus tag: EXIG_RS07125
• Protein ID: WP_012370260.1
• Coordinates: 1377761..1378015 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EXIG_RS07095	1373177..1373677	-	501	WP_012370254.1	DinB family protein	-
EXIG_RS07100	1373791..1375026	-	1236	WP_012370255.1	MFS transporter	-
EXIG_RS07105	1375155..1375442	-	288	WP_012370256.1	hypothetical protein	-
EXIG_RS07110	1375609..1376154	+	546	WP_012370257.1	GNAT family N-acetyltransferase	-
EXIG_RS07115	1376218..1376451	-	234	WP_012370258.1	hypothetical protein	-
EXIG_RS07120	1376478..1377602	-	1125	WP_012370259.1	diguanylate cyclase	-
EXIG_RS07125	1377761..1378015	+	255	WP_012370260.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
EXIG_RS07130	1378008..1378274	+	267	WP_041261583.1	Txe/YoeB family addiction module toxin	Toxin
EXIG_RS07135	1378451..1378867	+	417	WP_012370261.1	NAD(+)--rifampin ADP-ribosyltransferase	-
EXIG_RS15910	1379003..1379206	+	204	WP_041261585.1	hypothetical protein	-
EXIG_RS07145	1379216..1380004	-	789	WP_041261587.1	hypothetical protein	-
EXIG_RS07150	1380129..1380326	+	198	WP_012370263.1	hypothetical protein	-
EXIG_RS07155	1380476..1381279	+	804	WP_012370264.1	helix-turn-helix domain-containing protein	-
EXIG_RS07160	1381295..1381957	+	663	WP_012370265.1	M15 family metallopeptidase	-
EXIG_RS07165	1381954..1382220	+	267	WP_012370266.1	SPP1 phage holin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10561.99 Da
• Isoelectric Point: 9.8829

>T22803 WP_041261583.1 NC_010556:1378008-1378274 [Exiguobacterium sibiricum 255-15]
MSKVRLLFTDHGWEDYLYSQREDRKKLKRINTLIEDVKRNGNLTGIGKPEALKGNLQGFYSRRIDSEHRLVYRSTSEQVE
ILQCRYHY

Nucleotide

• Length: 267 bp

>T22803 NC_010556:1378008-1378274 [Exiguobacterium sibiricum 255-15]
ATGAGTAAGGTCCGTCTACTTTTTACGGATCATGGATGGGAAGACTATCTGTATTCGCAACGGGAAGACAGAAAAAAGCT
AAAACGGATCAATACGCTGATTGAAGACGTAAAACGAAACGGCAATTTAACTGGCATTGGTAAACCGGAAGCATTAAAAG
GAAATTTACAAGGCTTTTACAGCCGGCGAATTGACTCGGAACATCGCCTCGTTTACAGGTCGACGAGTGAACAGGTGGAA
ATCCTTCAATGCCGTTATCATTATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9954.28 Da
• Isoelectric Point: 4.5216

>AT22803 WP_012370260.1 NC_010556:1377761-1378015 [Exiguobacterium sibiricum 255-15]
MSIVIYSDARKNFKQILDQVHDDKEAVIISRKNNENAVLLSEEEYNRLMETIYLMRSPQNSVRLLESIDQLQQEKLTERT
LIDE

Nucleotide

• Length: 255 bp

>AT22803 NC_010556:1377761-1378015 [Exiguobacterium sibiricum 255-15]
ATGTCGATTGTCATATACAGTGATGCCCGTAAAAATTTTAAACAGATTTTAGATCAAGTGCATGATGATAAGGAAGCAGT
CATCATTTCACGAAAAAATAACGAAAATGCCGTGTTACTTTCTGAAGAAGAATACAATCGTTTGATGGAGACCATCTATT
TAATGCGAAGTCCTCAAAATTCAGTCCGTCTACTGGAGTCAATTGACCAGCTCCAACAAGAAAAGTTGACAGAAAGAACG
TTGATTGATGAGTAA

Structures

Antitoxin

• AlphaFold DB: B1YFG3