Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1223190..1223783 Replicon chromosome
Accession NZ_CP089309
Organism Thiocapsa bogorovii strain BBS

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag LT988_RS05500 Protein ID WP_232409222.1
Coordinates 1223505..1223783 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LT988_RS05495 Protein ID WP_232409221.1
Coordinates 1223190..1223492 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT988_RS05480 (LT988_05480) 1220199..1222535 - 2337 WP_232409218.1 BREX-1 system phosphatase PglZ type B -
LT988_RS05485 (LT988_05485) 1222624..1222884 - 261 WP_232409219.1 Txe/YoeB family addiction module toxin -
LT988_RS05490 (LT988_05490) 1222877..1223131 - 255 WP_232409220.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
LT988_RS05495 (LT988_05495) 1223190..1223492 - 303 WP_232409221.1 HigA family addiction module antitoxin Antitoxin
LT988_RS05500 (LT988_05500) 1223505..1223783 - 279 WP_232409222.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LT988_RS05505 (LT988_05505) 1223809..1224462 - 654 WP_232409223.1 DUF4276 family protein -
LT988_RS05510 (LT988_05510) 1224459..1225514 - 1056 WP_232409224.1 AAA family ATPase -
LT988_RS05515 (LT988_05515) 1225550..1228060 - 2511 WP_232409225.1 transposase -
LT988_RS05520 (LT988_05520) 1228111..1228485 - 375 WP_232409226.1 type II toxin-antitoxin system VapC family toxin -
LT988_RS05525 (LT988_05525) 1228482..1228682 - 201 WP_232409227.1 type II toxin-antitoxin system VapB family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(23-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-96)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.33 Da        Isoelectric Point: 10.5686

>T228006 WP_232409222.1 NZ_CP089309:c1223783-1223505 [Thiocapsa bogorovii]
MIKTFRCRDTEALFSARRVARFAHIERAALRKLVQLNLARVIDDMRAPPGNRLESLKGDRAGQWSVRINAQWRLCFRFSD
GDALDVEIVDYH

Download         Length: 279 bp

>T228006 NZ_CP123255:185375-185482 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11347.16 Da        Isoelectric Point: 5.7238

>AT228006 WP_232409221.1 NZ_CP089309:c1223492-1223190 [Thiocapsa bogorovii]
MTRELAPVSPGEMLMEEFLKPLALSQYALARAVHVPPRRINEIVHGKRAVTADTDLRLCRFFGLSEGWWLRLQADYDIAL
AKESMADVLSEIEPLPRGRD

Download         Length: 303 bp

>AT228006 NZ_CP123255:c185327-185261 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References