Detailed information of TA system TA227986

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 308804..309335
• Replicon: chromosome
• Accession: NZ_CP089301
• Organism: Novosphingobium kaempferiae strain Sx8-5

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: LO787_RS01465
• Protein ID: WP_232494120.1
• Coordinates: 308804..309073 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: LO787_RS01470
• Protein ID: WP_232494121.1
• Coordinates: 309081..309335 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO787_RS01450	306326..306661	-	336	WP_103098110.1	YbaB/EbfC family nucleoid-associated protein	-
LO787_RS01455	306663..308561	-	1899	WP_232494119.1	DNA polymerase III subunit gamma/tau	-
LO787_RS01465	308804..309073	-	270	WP_232494120.1	Txe/YoeB family addiction module toxin	Toxin
LO787_RS01470	309081..309335	-	255	WP_232494121.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LO787_RS01475	309389..309667	-	279	WP_232494122.1	ETC complex I subunit	-
LO787_RS01480	309713..312163	-	2451	WP_232494123.1	ATP-dependent helicase HrpB	-
LO787_RS01485	312384..314261	+	1878	WP_232494124.1	EAL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10427.84 Da
• Isoelectric Point: 9.6839

>T227986 WP_232494120.1 NZ_CP089301:c309073-308804 [Novosphingobium kaempferiae]
MKIVFASRAWEDYQHWVANDRATLERLNALVEQCRHTPFKGTGKPEPLKGELQGWWSRRINQADRLVYRVAGTGAEQRLE
IAQCRFHYA

Nucleotide

• Length: 270 bp

>T227986 NZ_CP123244:c4007972-4007658 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTATCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9443.66 Da
• Isoelectric Point: 4.4523

>AT227986 WP_232494121.1 NZ_CP089301:c309335-309081 [Novosphingobium kaempferiae]
MDVLSFSEARANFKALMDHVVDDRSPVIVTRQKAEAVVMVSLSDWNAMAETMHLLSTPANSQRLRDAVREFDMGEGEEHD
LVQP

Nucleotide

• Length: 255 bp

>AT227986 NZ_CP123244:c4008208-4007975 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG