Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 314630..315180 Replicon chromosome
Accession NZ_CP089296
Organism Methylobacterium currus strain TP-3

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LRS73_RS30055 Protein ID WP_232389064.1
Coordinates 314908..315180 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LRS73_RS30050 Protein ID WP_232389063.1
Coordinates 314630..314911 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRS73_RS30025 (LRS73_30025) 309861..310841 - 981 WP_232389058.1 extensin family protein -
LRS73_RS30030 (LRS73_30030) 310956..311816 - 861 WP_232389059.1 DMT family transporter -
LRS73_RS30035 (LRS73_30035) 312051..313439 + 1389 WP_232389060.1 PLP-dependent aminotransferase family protein -
LRS73_RS30040 (LRS73_30040) 313516..313797 - 282 WP_232389061.1 hypothetical protein -
LRS73_RS30045 (LRS73_30045) 313839..314465 + 627 WP_232389062.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
LRS73_RS30050 (LRS73_30050) 314630..314911 + 282 WP_232389063.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LRS73_RS30055 (LRS73_30055) 314908..315180 + 273 WP_232389064.1 Txe/YoeB family addiction module toxin Toxin
LRS73_RS30060 (LRS73_30060) 315458..316999 - 1542 WP_232389065.1 MFS transporter -
LRS73_RS30065 (LRS73_30065) 317182..318060 + 879 WP_232389066.1 LysR family transcriptional regulator -
LRS73_RS30075 (LRS73_30075) 318563..319435 - 873 Protein_265 HlyD family secretion protein -
LRS73_RS30080 (LRS73_30080) 319446..319640 - 195 WP_099957114.1 DUF1656 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10687.97 Da        Isoelectric Point: 6.2245

>T227985 WP_232389064.1 NZ_CP089296:314908-315180 [Methylobacterium currus]
MRLTFSDEAWNEYLFWQSESEATLHRINDLIKEVKRTPFTGTGEPEPLKFKLEGWWSRRISGEHRLVYRVSGSGAVQTLE
IAQCRWHYDD

Download         Length: 273 bp

>T227985 NZ_CP123244:3782938-3783216 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGCTCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10473.83 Da        Isoelectric Point: 5.6023

>AT227985 WP_232389063.1 NZ_CP089296:314630-314911 [Methylobacterium currus]
MTHVSLTELRQSIATHFDRVERDREELVVTRQGHEPLVLLPLAELESLRDTPHLLGTPAKARRLMRSIEQLDAGRGVERS
PIEPDQSKDAAEG

Download         Length: 282 bp

>AT227985 NZ_CP123244:3782675-3782935 [Escherichia coli]
ATGGCTGCAAATGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGGTGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References