227969

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4837585..4837997 Replicon chromosome
Accession NZ_CP089272
Organism Escherichia coli O157:H7 strain M1300706001A

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag LSI73_RS24520 Protein ID WP_000132630.1
Coordinates 4837656..4837997 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4837585..4837661 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSI73_RS24510 (4834212) 4834212..4835681 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
LSI73_RS24515 (4835681) 4835681..4837435 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- (4837585) 4837585..4837661 - 77 NuclAT_15 - Antitoxin
- (4837585) 4837585..4837661 - 77 NuclAT_15 - Antitoxin
- (4837585) 4837585..4837661 - 77 NuclAT_15 - Antitoxin
- (4837585) 4837585..4837661 - 77 NuclAT_15 - Antitoxin
- (4837585) 4837585..4837661 - 77 NuclAT_16 - Antitoxin
- (4837585) 4837585..4837661 - 77 NuclAT_16 - Antitoxin
- (4837585) 4837585..4837661 - 77 NuclAT_16 - Antitoxin
- (4837585) 4837585..4837661 - 77 NuclAT_16 - Antitoxin
LSI73_RS24520 (4837656) 4837656..4837997 + 342 WP_000132630.1 endoribonuclease SymE Toxin
LSI73_RS24525 (4838044) 4838044..4839207 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
LSI73_RS24530 (4839255) 4839255..4840136 - 882 WP_001304007.1 DUF262 domain-containing protein -
LSI73_RS24535 (4840279) 4840279..4840431 - 153 WP_001418365.1 hypothetical protein -
LSI73_RS24540 (4840574) 4840574..4841986 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4829784..4850999 21215


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T227969 WP_000132630.1 NZ_CP089272:4837656-4837997 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T227969 NZ_CP123240:c5015345-5015034 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 77 bp

>AT227969 NZ_CP089272:c4837661-4837585 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References