Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4966708..4967120 Replicon chromosome
Accession NZ_CP089270
Organism Escherichia coli O157:H7 strain M1300706002

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag LSI72_RS25370 Protein ID WP_000132630.1
Coordinates 4966779..4967120 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4966708..4966784 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSI72_RS25360 (4963335) 4963335..4964804 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
LSI72_RS25365 (4964804) 4964804..4966558 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- (4966708) 4966708..4966784 - 77 NuclAT_16 - Antitoxin
- (4966708) 4966708..4966784 - 77 NuclAT_16 - Antitoxin
- (4966708) 4966708..4966784 - 77 NuclAT_16 - Antitoxin
- (4966708) 4966708..4966784 - 77 NuclAT_16 - Antitoxin
- (4966708) 4966708..4966784 - 77 NuclAT_17 - Antitoxin
- (4966708) 4966708..4966784 - 77 NuclAT_17 - Antitoxin
- (4966708) 4966708..4966784 - 77 NuclAT_17 - Antitoxin
- (4966708) 4966708..4966784 - 77 NuclAT_17 - Antitoxin
LSI72_RS25370 (4966779) 4966779..4967120 + 342 WP_000132630.1 endoribonuclease SymE Toxin
LSI72_RS25375 (4967167) 4967167..4968330 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
LSI72_RS25380 (4968378) 4968378..4969259 - 882 WP_001304007.1 DUF262 domain-containing protein -
LSI72_RS25385 (4969402) 4969402..4969554 - 153 WP_001418365.1 hypothetical protein -
LSI72_RS25390 (4969697) 4969697..4971109 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4958907..4980134 21227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T227935 WP_000132630.1 NZ_CP089270:4966779-4967120 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T227935 NZ_CP123237:c2468499-2468323 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 77 bp

>AT227935 NZ_CP089270:c4966784-4966708 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References