Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | symER/SymE(toxin) |
Location | 4966708..4967120 | Replicon | chromosome |
Accession | NZ_CP089270 | ||
Organism | Escherichia coli O157:H7 strain M1300706002 |
Toxin (Protein)
Gene name | symE | Uniprot ID | Q8FA88 |
Locus tag | LSI72_RS25370 | Protein ID | WP_000132630.1 |
Coordinates | 4966779..4967120 (+) | Length | 114 a.a. |
Antitoxin (RNA)
Gene name | symR | ||
Locus tag | - | ||
Coordinates | 4966708..4966784 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LSI72_RS25360 (4963335) | 4963335..4964804 | + | 1470 | WP_001302468.1 | type I restriction-modification system subunit M | - |
LSI72_RS25365 (4964804) | 4964804..4966558 | + | 1755 | WP_000110082.1 | restriction endonuclease subunit S | - |
- (4966708) | 4966708..4966784 | - | 77 | NuclAT_16 | - | Antitoxin |
- (4966708) | 4966708..4966784 | - | 77 | NuclAT_16 | - | Antitoxin |
- (4966708) | 4966708..4966784 | - | 77 | NuclAT_16 | - | Antitoxin |
- (4966708) | 4966708..4966784 | - | 77 | NuclAT_16 | - | Antitoxin |
- (4966708) | 4966708..4966784 | - | 77 | NuclAT_17 | - | Antitoxin |
- (4966708) | 4966708..4966784 | - | 77 | NuclAT_17 | - | Antitoxin |
- (4966708) | 4966708..4966784 | - | 77 | NuclAT_17 | - | Antitoxin |
- (4966708) | 4966708..4966784 | - | 77 | NuclAT_17 | - | Antitoxin |
LSI72_RS25370 (4966779) | 4966779..4967120 | + | 342 | WP_000132630.1 | endoribonuclease SymE | Toxin |
LSI72_RS25375 (4967167) | 4967167..4968330 | - | 1164 | WP_001304006.1 | DUF1524 domain-containing protein | - |
LSI72_RS25380 (4968378) | 4968378..4969259 | - | 882 | WP_001304007.1 | DUF262 domain-containing protein | - |
LSI72_RS25385 (4969402) | 4969402..4969554 | - | 153 | WP_001418365.1 | hypothetical protein | - |
LSI72_RS25390 (4969697) | 4969697..4971109 | + | 1413 | WP_000199295.1 | PLP-dependent aminotransferase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | espX6 | 4958907..4980134 | 21227 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12294.13 Da Isoelectric Point: 8.4982
>T227935 WP_000132630.1 NZ_CP089270:4966779-4967120 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
Download Length: 342 bp
>T227935 NZ_CP123237:c2468499-2468323 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 77 bp
>AT227935 NZ_CP089270:c4966784-4966708 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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