Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 6927203..6927900 Replicon chromosome
Accession NZ_CP089227
Organism Nocardia asteroides strain FDAARGOS_1622

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag LT345_RS32105 Protein ID WP_036835380.1
Coordinates 6927532..6927900 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LT345_RS32100 Protein ID WP_019049601.1
Coordinates 6927203..6927535 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT345_RS32070 (LT345_32070) 6922511..6923473 - 963 WP_019049607.1 hypothetical protein -
LT345_RS32075 (LT345_32075) 6923588..6924037 + 450 WP_022566140.1 MarR family transcriptional regulator -
LT345_RS32080 (LT345_32080) 6924098..6924550 - 453 WP_019049605.1 SRPBCC family protein -
LT345_RS32085 (LT345_32085) 6924826..6925602 + 777 WP_022566141.1 AfsA-related hotdog domain-containing protein -
LT345_RS32090 (LT345_32090) 6925599..6926309 + 711 WP_019049603.1 HAD-IB family hydrolase -
LT345_RS32095 (LT345_32095) 6926303..6927145 + 843 WP_019049602.1 hypothetical protein -
LT345_RS32100 (LT345_32100) 6927203..6927535 - 333 WP_019049601.1 helix-turn-helix transcriptional regulator Antitoxin
LT345_RS32105 (LT345_32105) 6927532..6927900 - 369 WP_036835380.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LT345_RS32110 (LT345_32110) 6927980..6929233 - 1254 WP_022566143.1 NADH:flavin oxidoreductase/NADH oxidase family protein -
LT345_RS32115 (LT345_32115) 6929409..6930338 + 930 WP_019049598.1 acetoacetate decarboxylase family protein -
LT345_RS32120 (LT345_32120) 6930335..6931915 + 1581 WP_019049597.1 succinic semialdehyde dehydrogenase -
LT345_RS32125 (LT345_32125) 6931966..6932649 + 684 WP_019049596.1 type 1 glutamine amidotransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-97)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13678.48 Da        Isoelectric Point: 4.9473

>T227876 WP_036835380.1 NZ_CP089227:c6927900-6927532 [Nocardia asteroides]
VTWEIVLHPEVESWFLAICGTDPETGDLIERAIDHLASEGPSLGRPLVDRIKGSRYHNMKELRPASTGTTEVRILFAFDP
ARAAAMLVAGDKSNFWQGWYSEAIPLADKRFTEHLEALKEQS

Download         Length: 369 bp

>T227876 NZ_CP123214:10742-11014 [Pseudomonas amygdali pv. aesculi]
GTGCTAGTTGAGTGGCTTCCACAAGCTTTGGAGGCACTGGAGGAAATCGCCGGCTACCTAGCCGAGCGCAACCCTTATGC
TGCCGAGCAAATGCAGGCCACCCTTGAGGCCACGGTCGAGGCTCTCCCCCTGCACCCTTACATCCACCGTCCCGGCCGTG
TTCCAGGAACGCGCGAAGCGGTTGTGCATCCCAACTACCTGGTTGTCTACCGCGTCGGTACAGAGCGCATCAGCATCGTG
GACGTCCTGCACGCCCGCCAAGAGTACCCCTAG

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12068.60 Da        Isoelectric Point: 8.6047

>AT227876 WP_019049601.1 NZ_CP089227:c6927535-6927203 [Nocardia asteroides]
MSTEFSKWTDVKARARQQDPRSEAEQTAGALRADERHESYLRGHQLAEIRKAMGMTQVALAEALGVTQARVSKIERGEIS
GIDAIRAYVTALGGSVDVVVRLGDRTWNVA

Download         Length: 333 bp

>AT227876 NZ_CP123214:10567-10752 [Pseudomonas amygdali pv. aesculi]
ATGAGCATTCAACTTGACCCTCGCGTCTCGGAGTTCGAGACCCAGGAACAGGCCGACAATTACGACCGTTGGTTTCGCCT
GCGTATCGAGCGCAGTTTGGCCGATCCGCGTCCACCCGTGCCGCACGATGAAGCAATGGCTCGCGTCAGAGCCATGATTG
AGGCAAAGCGCCGCCGTGCTAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References