227873

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5109203..5109791 Replicon chromosome
Accession NZ_CP089227
Organism Nocardia asteroides strain FDAARGOS_1622

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag LT345_RS23765 Protein ID WP_030200292.1
Coordinates 5109510..5109791 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LT345_RS23760 Protein ID WP_019045366.1
Coordinates 5109203..5109496 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LT345_RS23735 (LT345_23735) 5104545..5105351 - 807 WP_197724382.1 sulfurtransferase -
LT345_RS23740 (LT345_23740) 5105579..5106775 + 1197 WP_019045370.1 benzoate/H(+) symporter BenE family transporter -
LT345_RS23745 (LT345_23745) 5106779..5107114 - 336 WP_126405637.1 hypothetical protein -
LT345_RS23750 (LT345_23750) 5107125..5107310 + 186 WP_030200277.1 hypothetical protein -
LT345_RS23755 (LT345_23755) 5107442..5109061 - 1620 WP_019045367.1 restriction endonuclease -
LT345_RS23760 (LT345_23760) 5109203..5109496 - 294 WP_019045366.1 HigA family addiction module antitoxin Antitoxin
LT345_RS23765 (LT345_23765) 5109510..5109791 - 282 WP_030200292.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LT345_RS23770 (LT345_23770) 5109840..5110331 - 492 WP_019045364.1 Lrp/AsnC family transcriptional regulator -
LT345_RS23775 (LT345_23775) 5110502..5111584 + 1083 WP_019045363.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
LT345_RS23780 (LT345_23780) 5111581..5112555 + 975 WP_019045362.1 alpha-ketoacid dehydrogenase subunit beta -
LT345_RS23785 (LT345_23785) 5112571..5113893 + 1323 WP_019045361.1 dihydrolipoamide acetyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.43 Da        Isoelectric Point: 10.2158

>T227873 WP_030200292.1 NZ_CP089227:c5109791-5109510 [Nocardia asteroides]
VIRSFGDRDTERLWHREHVKTFDSRILRVALRKLAILDAAVSLGELRVPPGNRLEALKGNRKGQYSLRINEQWRICFVWT
DAGPEQVAIVDYH

Download         Length: 282 bp

>T227873 NZ_CP123211:54343-54669 [Pseudomonas amygdali pv. aesculi]
ATGATGCGAGGTGACCTAGTCACCGTCGCCATGCAAGGTGACTTTGGTAAACCAAGACCCGCCTTGGTAATTCAGGCAAA
CCAATTCAGCGAACACACCAGCGTTACCGTGCTGCCAGTGACCAGCACCCTAGTCGCAGCACCGCTGCTGCGCATCACCG
TTCAGCCGACCGCAGAAAACGGCTTGCAGAAGCCTTCTCAGGTCATGCTAGACAAGACCATGACACTCAAGCGTGAAAAA
ATAGGTCCGACTTTTGGGCATATCGGAGTGGATTCAATGGTGGAGGTGGAGCGCTGTTTAGCCGTGTTCTTGGGTATCGC
CAATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10807.56 Da        Isoelectric Point: 9.8274

>AT227873 WP_019045366.1 NZ_CP089227:c5109496-5109203 [Nocardia asteroides]
MGKLAPVHPGEVLKEDFIEPLGITQHRVAVAIGVPPRRINEIVHGKRRITADTALRLGRYFGTSDIFWLNLQNRYDLEIE
RDAIGAALAAIQPLRVA

Download         Length: 294 bp

>AT227873 NZ_CP123211:54122-54346 [Pseudomonas amygdali pv. aesculi]
ATGCCTACATCCCATGTAAATGCCCGCGTTCAACGCCATCGCGACGCGCTGCGTGCGGCTGGCCTACGGCCCATTCAGAT
TTGGGTTCCCGATACCCGGCGGCCAGACTTTGCACAGGAGTGCCATCGACAGTGCCTGTTGGTTGCTCAGGCAGACATGG
CCAATACCTATATGCAGGGGTTGATGGACGAAGCCTTAGACGATGTTGAGGGTTGGACGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References