Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5150371..5150959 Replicon chromosome
Accession NZ_CP089212
Organism Nocardia asteroides strain FDAARGOS_1621

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag LTT85_RS24070 Protein ID WP_232996921.1
Coordinates 5150371..5150652 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LTT85_RS24075 Protein ID WP_232996922.1
Coordinates 5150666..5150959 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTT85_RS24050 (LTT85_24050) 5146259..5147581 - 1323 WP_232996917.1 dihydrolipoamide acetyltransferase family protein -
LTT85_RS24055 (LTT85_24055) 5147599..5148573 - 975 WP_232996918.1 alpha-ketoacid dehydrogenase subunit beta -
LTT85_RS24060 (LTT85_24060) 5148570..5149652 - 1083 WP_232996919.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
LTT85_RS24065 (LTT85_24065) 5149823..5150314 + 492 WP_232996920.1 Lrp/AsnC family transcriptional regulator -
LTT85_RS24070 (LTT85_24070) 5150371..5150652 + 282 WP_232996921.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LTT85_RS24075 (LTT85_24075) 5150666..5150959 + 294 WP_232996922.1 HigA family addiction module antitoxin Antitoxin
LTT85_RS24080 (LTT85_24080) 5151056..5151577 + 522 WP_232996923.1 hypothetical protein -
LTT85_RS24085 (LTT85_24085) 5151584..5152795 - 1212 WP_232996924.1 benzoate/H(+) symporter BenE family transporter -
LTT85_RS24090 (LTT85_24090) 5153197..5154003 + 807 WP_233001682.1 sulfurtransferase -
LTT85_RS24095 (LTT85_24095) 5154194..5154880 - 687 WP_232996925.1 HNH endonuclease family protein -
LTT85_RS24100 (LTT85_24100) 5154941..5155303 - 363 WP_232996926.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-64)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10799.33 Da        Isoelectric Point: 9.1739

>T227810 WP_232996921.1 NZ_CP089212:5150371-5150652 [Nocardia asteroides]
VIRSFDDRDTERLWRREHVAKFDSRIVRVALRKLAILDAVVSLGELGVPPGNRLEALKGNRKGQHSVRINDQWRICFVWT
DAGPEHVEIVDYH

Download         Length: 282 bp

>T227810 NZ_CP123046:261702-261932 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10840.56 Da        Isoelectric Point: 7.3187

>AT227810 WP_232996922.1 NZ_CP089212:5150666-5150959 [Nocardia asteroides]
MGKLAPVHPGEVLMDDFIEPLGITQHRVAVAIGVPPRRINEIVHGKRRITADTALRLGRYFGTSDLFWLNLQNRYDLEIE
RDAIGDALAAIQPLRVA

Download         Length: 294 bp

>AT227810 NZ_CP123046:261929-262288 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References