Detailed information of TA system TA227799

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1445419..1445599
• Replicon: chromosome
• Accession: NZ_CP089165
• Organism: Staphylococcus aureus strain UNC_SaCF07

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: LTK18_RS07425
• Protein ID: WP_001801861.1
• Coordinates: 1445504..1445599 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1445419..1445476 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LTK18_RS07395 (LTK18_07395)	1441128..1441262	+	135	WP_001791797.1	hypothetical protein	-
LTK18_RS07400 (LTK18_07400)	1441426..1442982	+	1557	WP_000028669.1	type I restriction-modification system subunit M	-
LTK18_RS07405 (LTK18_07405)	1442975..1444204	+	1230	WP_000072627.1	restriction endonuclease subunit S	-
LTK18_RS07410 (LTK18_07410)	1444746..1445156	+	411	WP_001808705.1	IS21 family transposase	-
LTK18_RS07415 (LTK18_07415)	1445141..1445302	+	162	Protein_1428	transposase	-
LTK18_RS07420 (LTK18_07420)	1445280..1445381	-	102	WP_001792025.1	hypothetical protein	-
-	1445419..1445476	+	58	-	-	Antitoxin
LTK18_RS07425 (LTK18_07425)	1445504..1445599	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
LTK18_RS07430 (LTK18_07430)	1445744..1446756	+	1013	Protein_1431	IS3 family transposase	-
LTK18_RS07435 (LTK18_07435)	1446954..1447526	-	573	WP_000414216.1	hypothetical protein	-
LTK18_RS07440 (LTK18_07440)	1447627..1447968	-	342	WP_000627540.1	DUF3969 family protein	-
LTK18_RS07445 (LTK18_07445)	1448009..1448635	-	627	WP_000669024.1	hypothetical protein	-
LTK18_RS07450 (LTK18_07450)	1448710..1449705	-	996	WP_000070642.1	DUF4352 domain-containing protein	-
LTK18_RS07455 (LTK18_07455)	1449786..1450436	-	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / hlgA / lukD	1418586..1469617	51031

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T227799 WP_001801861.1 NZ_CP089165:c1445599-1445504 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T227799 NZ_CP123043:363764-364111 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATTCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGAGCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT227799 NZ_CP089165:1445419-1445476 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin