Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2630987..2631504 Replicon chromosome
Accession NZ_CP089162
Organism Staphylococcus aureus strain UNC_SaCF11

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag LTK16_RS13100 Protein ID WP_000113262.1
Coordinates 2631238..2631504 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag LTK16_RS13095 Protein ID WP_000584502.1
Coordinates 2630987..2631238 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK16_RS13065 (2626688) 2626688..2627407 + 720 WP_000479576.1 amino acid ABC transporter permease -
LTK16_RS13070 (2627404) 2627404..2628135 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
LTK16_RS13075 (2628232) 2628232..2629482 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
LTK16_RS13080 (2629737) 2629737..2630096 + 360 WP_000819847.1 DUF4467 domain-containing protein -
LTK16_RS13085 (2630115) 2630115..2630714 + 600 WP_000162813.1 DsbA family protein -
LTK16_RS13090 (2630721) 2630721..2630822 + 102 WP_001791744.1 hypothetical protein -
LTK16_RS13095 (2630987) 2630987..2631238 + 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LTK16_RS13100 (2631238) 2631238..2631504 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
LTK16_RS13105 (2631539) 2631539..2631610 + 72 Protein_2543 hypothetical protein -
LTK16_RS13110 (2631799) 2631799..2633349 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
LTK16_RS13115 (2633535) 2633535..2634002 + 468 WP_000153344.1 SRPBCC domain-containing protein -
LTK16_RS13120 (2634086) 2634086..2634268 + 183 WP_000230294.1 hypothetical protein -
LTK16_RS13125 (2634485) 2634485..2635309 + 825 WP_000572040.1 formate/nitrite transporter family protein -
LTK16_RS13130 (2635542) 2635542..2636078 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T227787 WP_000113262.1 NZ_CP089162:2631238-2631504 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T227787 NZ_CP123040:337793-338161 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCTGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT227787 WP_000584502.1 NZ_CP089162:2630987-2631238 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT227787 NZ_CP123040:337575-337796 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References