Detailed information of TA system TA227785

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2605972..2606156
• Replicon: chromosome
• Accession: NZ_CP089162
• Organism: Staphylococcus aureus strain UNC_SaCF11

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: LTK16_RS12965
• Protein ID: WP_000482650.1
• Coordinates: 2605972..2606079 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2606096..2606156 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LTK16_RS12940	2601334..2601807	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
LTK16_RS12945	2601930..2603141	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
LTK16_RS12950	2603323..2603982	-	660	WP_000831298.1	membrane protein	-
LTK16_RS12955	2604042..2605184	-	1143	WP_001176863.1	glycerate kinase	-
LTK16_RS12960	2605452..2605838	+	387	WP_000779358.1	flippase GtxA	-
LTK16_RS12965	2605972..2606079	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2606096..2606156	-	61	-	-	Antitoxin
LTK16_RS12970	2606707..2608470	+	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
LTK16_RS12975	2608495..2610228	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
LTK16_RS12980	2610459..2610626	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T227785 WP_000482650.1 NZ_CP089162:2605972-2606079 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T227785 NZ_CP123037:93559-93975 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT227785 NZ_CP089162:c2606156-2606096 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin