Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2574133..2574656 Replicon chromosome
Accession NZ_CP089162
Organism Staphylococcus aureus strain UNC_SaCF11

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag LTK16_RS12825 Protein ID WP_000074048.1
Coordinates 2574390..2574656 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag LTK16_RS12820 Protein ID WP_000587616.1
Coordinates 2574133..2574390 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK16_RS12795 (2569213) 2569213..2570406 + 1194 WP_000675401.1 MFS transporter -
LTK16_RS12800 (2570630) 2570630..2571379 - 750 WP_000072444.1 CPBP family lipoprotein N-acylation protein LnsB -
LTK16_RS12805 (2571574) 2571574..2573151 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
LTK16_RS12810 (2573319) 2573319..2573774 - 456 WP_000732082.1 DUF1307 domain-containing protein -
LTK16_RS12815 (2573833) 2573833..2574027 + 195 WP_001790145.1 hypothetical protein -
LTK16_RS12820 (2574133) 2574133..2574390 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LTK16_RS12825 (2574390) 2574390..2574656 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
LTK16_RS12830 (2575011) 2575011..2576087 + 1077 WP_001076671.1 M42 family metallopeptidase -
LTK16_RS12835 (2576335) 2576335..2576997 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
LTK16_RS12840 (2576990) 2576990..2577766 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
LTK16_RS12845 (2578162) 2578162..2579349 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T227784 WP_000074048.1 NZ_CP089162:2574390-2574656 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T227784 NZ_CP123037:c87158-86853 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTCTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT227784 WP_000587616.1 NZ_CP089162:2574133-2574390 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT227784 NZ_CP123037:c87378-87160 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATACAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References