Detailed information of TA system TA227781

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 367484..367666
• Replicon: chromosome
• Accession: NZ_CP089162
• Organism: Staphylococcus aureus strain UNC_SaCF11

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: LTK16_RS02110
• Protein ID: WP_001801861.1
• Coordinates: 367571..367666 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	367484..367543 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LTK16_RS02095	366622..366999	+	378	WP_001037045.1	DUF1433 domain-containing protein	-
LTK16_RS02100	367193..367369	+	177	Protein_368	transposase	-
LTK16_RS02105	367347..367448	-	102	WP_001791893.1	hypothetical protein	-
-	367484..367543	+	60	-	-	Antitoxin
LTK16_RS02110	367571..367666	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
LTK16_RS02115	367869..368012	+	144	WP_001549059.1	transposase	-
LTK16_RS02120	368616..368999	+	384	WP_000070811.1	hypothetical protein	-
LTK16_RS02125	369010..369186	+	177	WP_000375476.1	hypothetical protein	-
LTK16_RS02130	369188..369373	+	186	WP_000809857.1	hypothetical protein	-
LTK16_RS02135	369487..370128	+	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
LTK16_RS02140	370346..370897	-	552	WP_000414205.1	hypothetical protein	-
LTK16_RS02145	370995..371339	-	345	WP_000627551.1	DUF3969 family protein	-
LTK16_RS02150	371380..372006	-	627	Protein_378	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	334395..405106	70711

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T227781 WP_001801861.1 NZ_CP089162:c367666-367571 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T227781 NZ_CP123036:3577851-3578069 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT227781 NZ_CP089162:367484-367543 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin