Detailed information of TA system TA227771

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 32053..32316
• Replicon: chromosome
• Accession: NZ_CP089162
• Organism: Staphylococcus aureus strain UNC_SaCF11

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: LTK16_RS00140
• Protein ID: WP_001802298.1
• Coordinates: 32053..32157 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	32152..32316 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LTK16_RS00110	27437..28219	+	783	WP_000908176.1	ABC transporter ATP-binding protein	-
LTK16_RS00115	28287..29144	+	858	WP_000370924.1	HAD family hydrolase	-
LTK16_RS00125	29849..29941	-	93	WP_001790138.1	hypothetical protein	-
LTK16_RS00130	30230..31366	+	1137	WP_000115564.1	SAP domain-containing protein	-
LTK16_RS00135	31409..31892	+	484	Protein_16	recombinase family protein	-
LTK16_RS00140	32053..32157	+	105	WP_001802298.1	hypothetical protein	Toxin
-	32152..32316	-	165	-	-	Antitoxin
LTK16_RS00150	32657..33748	-	1092	WP_000495671.1	lytic regulatory protein	-
LTK16_RS00155	34014..34994	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
LTK16_RS00160	34996..35316	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
LTK16_RS00165	35468..36133	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T227771 WP_001802298.1 NZ_CP089162:32053-32157 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T227771 NZ_CP123036:1344672-1345070 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT227771 NZ_CP089162:c32316-32152 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin