Detailed information of TA system TA227768

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2587487..2587667
• Replicon: chromosome
• Accession: NZ_CP089161
• Organism: Staphylococcus aureus strain UNC_SaCF13

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: LTK21_RS12520
• Protein ID: WP_001801861.1
• Coordinates: 2587487..2587582 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2587610..2587667 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LTK21_RS12490 (LTK21_12490)	2582650..2583300	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
LTK21_RS12495 (LTK21_12495)	2583381..2584376	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
LTK21_RS12500 (LTK21_12500)	2584451..2585077	+	627	WP_160177496.1	hypothetical protein	-
LTK21_RS12505 (LTK21_12505)	2585118..2585459	+	342	WP_000627540.1	DUF3969 family protein	-
LTK21_RS12510 (LTK21_12510)	2585560..2586132	+	573	WP_000414216.1	hypothetical protein	-
LTK21_RS12515 (LTK21_12515)	2586330..2587342	-	1013	Protein_2460	IS3 family transposase	-
LTK21_RS12520 (LTK21_12520)	2587487..2587582	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2587610..2587667	-	58	-	-	Antitoxin
LTK21_RS12525 (LTK21_12525)	2587705..2587806	+	102	Protein_2462	hypothetical protein	-
LTK21_RS12530 (LTK21_12530)	2587784..2587945	-	162	Protein_2463	transposase	-
LTK21_RS12535 (LTK21_12535)	2587930..2588340	-	411	WP_001808705.1	IS21 family transposase	-
LTK21_RS12540 (LTK21_12540)	2588882..2590111	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
LTK21_RS12545 (LTK21_12545)	2590104..2591660	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
LTK21_RS12550 (LTK21_12550)	2591824..2591958	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	2581892..2614499	32607

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T227768 WP_001801861.1 NZ_CP089161:2587487-2587582 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T227768 NZ_CP123036:903714-904121 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT227768 NZ_CP089161:c2587667-2587610 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin