Detailed information of TA system TA227762

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 375597..375781
• Replicon: chromosome
• Accession: NZ_CP089161
• Organism: Staphylococcus aureus strain UNC_SaCF13

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: LTK21_RS01950
• Protein ID: WP_000482652.1
• Coordinates: 375674..375781 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	375597..375657 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LTK21_RS01935 (LTK21_01935)	371052..371183	-	132	WP_223197975.1	hypothetical protein	-
LTK21_RS01940 (LTK21_01940)	371450..373183	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
LTK21_RS01945 (LTK21_01945)	373208..374971	-	1764	WP_232043697.1	ABC transporter ATP-binding protein	-
-	375597..375657	+	61	-	-	Antitoxin
LTK21_RS01950 (LTK21_01950)	375674..375781	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
LTK21_RS01955 (LTK21_01955)	375915..376301	-	387	WP_000779360.1	flippase GtxA	-
LTK21_RS01960 (LTK21_01960)	376569..377711	+	1143	WP_001176863.1	glycerate kinase	-
LTK21_RS01965 (LTK21_01965)	377771..378430	+	660	WP_000831298.1	membrane protein	-
LTK21_RS01970 (LTK21_01970)	378612..379823	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
LTK21_RS01975 (LTK21_01975)	379946..380419	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T227762 WP_000482652.1 NZ_CP089161:c375781-375674 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T227762 NZ_CP123031:82049-82429 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTAGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT227762 NZ_CP089161:375597-375657 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin