Detailed information of TA system TA227753

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2832845..2833108
• Replicon: chromosome
• Accession: NZ_CP089159
• Organism: Staphylococcus aureus strain UNC_SaCF18

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: LTK20_RS14350
• Protein ID: WP_001802298.1
• Coordinates: 2832845..2832949 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2832944..2833108 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LTK20_RS14320	2828229..2829011	+	783	WP_000908176.1	ABC transporter ATP-binding protein	-
LTK20_RS14325	2829079..2829936	+	858	WP_000370924.1	HAD family hydrolase	-
LTK20_RS14335	2830641..2830733	-	93	WP_001790138.1	hypothetical protein	-
LTK20_RS14340	2831022..2832158	+	1137	WP_000115564.1	SAP domain-containing protein	-
LTK20_RS14345	2832201..2832684	+	484	Protein_2791	recombinase family protein	-
LTK20_RS14350	2832845..2832949	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2832944..2833108	-	165	-	-	Antitoxin
LTK20_RS14360	2833449..2834540	-	1092	WP_000495671.1	lytic regulatory protein	-
LTK20_RS14365	2834806..2835783	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
LTK20_RS14370	2835785..2836105	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
LTK20_RS14375	2836257..2836922	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T227753 WP_001802298.1 NZ_CP089159:2832845-2832949 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T227753 NZ_CP123029:2697418-2697525 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGTGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT227753 NZ_CP089159:c2833108-2832944 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin