227752

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2567864..2568381 Replicon chromosome
Accession NZ_CP089159
Organism Staphylococcus aureus strain UNC_SaCF18

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag LTK20_RS12965 Protein ID WP_000113262.1
Coordinates 2568115..2568381 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag LTK20_RS12960 Protein ID WP_000584502.1
Coordinates 2567864..2568115 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK20_RS12930 (2563565) 2563565..2564284 + 720 WP_000479576.1 amino acid ABC transporter permease -
LTK20_RS12935 (2564281) 2564281..2565012 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
LTK20_RS12940 (2565109) 2565109..2566359 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
LTK20_RS12945 (2566614) 2566614..2566973 + 360 WP_000819847.1 DUF4467 domain-containing protein -
LTK20_RS12950 (2566992) 2566992..2567591 + 600 WP_000162813.1 DsbA family protein -
LTK20_RS12955 (2567598) 2567598..2567699 + 102 WP_001791744.1 hypothetical protein -
LTK20_RS12960 (2567864) 2567864..2568115 + 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LTK20_RS12965 (2568115) 2568115..2568381 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
LTK20_RS12970 (2568416) 2568416..2568487 + 72 Protein_2525 hypothetical protein -
LTK20_RS12975 (2568676) 2568676..2570226 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
LTK20_RS12980 (2570412) 2570412..2570879 + 468 WP_000153344.1 SRPBCC domain-containing protein -
LTK20_RS12985 (2570963) 2570963..2571145 + 183 WP_000230294.1 hypothetical protein -
LTK20_RS12990 (2571362) 2571362..2572186 + 825 WP_000572040.1 formate/nitrite transporter family protein -
LTK20_RS12995 (2572419) 2572419..2572955 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T227752 WP_000113262.1 NZ_CP089159:2568115-2568381 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T227752 NZ_CP123029:2696882-2696989 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT227752 WP_000584502.1 NZ_CP089159:2567864-2568115 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT227752 NZ_CP123029:c2696835-2696769 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References