Detailed information of TA system TA227750

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2542849..2543033
• Replicon: chromosome
• Accession: NZ_CP089159
• Organism: Staphylococcus aureus strain UNC_SaCF18

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: LTK20_RS12830
• Protein ID: WP_000482650.1
• Coordinates: 2542849..2542956 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2542973..2543033 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LTK20_RS12805	2538211..2538684	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
LTK20_RS12810	2538807..2540018	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
LTK20_RS12815	2540200..2540859	-	660	WP_000831298.1	membrane protein	-
LTK20_RS12820	2540919..2542061	-	1143	WP_001176863.1	glycerate kinase	-
LTK20_RS12825	2542329..2542715	+	387	WP_000779358.1	flippase GtxA	-
LTK20_RS12830	2542849..2542956	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2542973..2543033	-	61	-	-	Antitoxin
LTK20_RS12835	2543584..2545347	+	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
LTK20_RS12840	2545372..2547105	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
LTK20_RS12845	2547336..2547503	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T227750 WP_000482650.1 NZ_CP089159:2542849-2542956 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T227750 NZ_CP123029:2079874-2079977 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 61 bp

>AT227750 NZ_CP089159:c2543033-2542973 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin