Detailed information of TA system TA227739

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 90101..90439
• Replicon: chromosome
• Accession: NZ_CP089159
• Organism: Staphylococcus aureus strain UNC_SaCF18

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: LTK20_RS00550
• Protein ID: WP_011447039.1
• Coordinates: 90101..90277 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	90265..90439 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LTK20_RS00530	85336..89121	+	3786	WP_000582165.1	phage tail spike protein	-
LTK20_RS00535	89111..89263	+	153	WP_001153681.1	hypothetical protein	-
LTK20_RS00540	89310..89597	+	288	WP_001040261.1	hypothetical protein	-
LTK20_RS00545	89655..89951	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
LTK20_RS00550	90101..90277	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	90265..90439	-	175	-	-	Antitoxin
LTK20_RS00560	90489..90743	+	255	WP_000611512.1	phage holin	-
LTK20_RS00565	90755..91510	+	756	WP_000861038.1	CHAP domain-containing protein	-
LTK20_RS00570	91701..92192	+	492	WP_000919350.1	staphylokinase	-
LTK20_RS00575	92842..93177	+	336	Protein_111	SH3 domain-containing protein	-
LTK20_RS00580	93272..93721	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
LTK20_RS00585	94406..94756	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
LTK20_RS00590	94809..95069	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	35789..94756	58967

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T227739 WP_011447039.1 NZ_CP089159:90101-90277 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T227739 NZ_CP123029:292355-292585 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT227739 NZ_CP089159:c90439-90265 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin