Detailed information of TA system TA227736

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1146554..1146738
• Replicon: chromosome
• Accession: NZ_CP089157
• Organism: Staphylococcus aureus strain UNC_SaCF30

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: LTK17_RS05790
• Protein ID: WP_000482647.1
• Coordinates: 1146631..1146738 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1146554..1146614 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LTK17_RS05775 (LTK17_05775)	1142064..1142231	-	168	Protein_1100	hypothetical protein	-
LTK17_RS05780 (LTK17_05780)	1142462..1144195	-	1734	WP_232043824.1	ABC transporter ATP-binding protein	-
LTK17_RS05785 (LTK17_05785)	1144220..1145983	-	1764	WP_001064829.1	ABC transporter ATP-binding protein	-
-	1146554..1146614	+	61	-	-	Antitoxin
LTK17_RS05790 (LTK17_05790)	1146631..1146738	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
LTK17_RS05795 (LTK17_05795)	1146872..1147258	-	387	WP_000779351.1	flippase GtxA	-
LTK17_RS05800 (LTK17_05800)	1147526..1148668	+	1143	WP_001176855.1	glycerate kinase	-
LTK17_RS05805 (LTK17_05805)	1148728..1149387	+	660	WP_000831298.1	membrane protein	-
LTK17_RS05810 (LTK17_05810)	1149569..1150780	+	1212	WP_001191919.1	multidrug effflux MFS transporter	-
LTK17_RS05815 (LTK17_05815)	1150903..1151376	-	474	WP_000456496.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T227736 WP_000482647.1 NZ_CP089157:c1146738-1146631 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T227736 NZ_CP123025:c79480-79175 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTCTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT227736 NZ_CP089157:1146554-1146614 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin