227735

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1121252..1121769 Replicon chromosome
Accession NZ_CP089157
Organism Staphylococcus aureus strain UNC_SaCF30

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag LTK17_RS05655 Protein ID WP_000251928.1
Coordinates 1121252..1121518 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag LTK17_RS05660 Protein ID WP_000584497.1
Coordinates 1121518..1121769 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK17_RS05630 (LTK17_05630) 1116460..1116996 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
LTK17_RS05635 (LTK17_05635) 1117464..1118288 - 825 WP_000594640.1 formate/nitrite transporter family protein -
LTK17_RS05640 (LTK17_05640) 1118491..1118673 - 183 WP_000079140.1 hypothetical protein -
LTK17_RS05645 (LTK17_05645) 1118759..1119226 - 468 WP_000153340.1 SRPBCC domain-containing protein -
LTK17_RS05650 (LTK17_05650) 1119412..1120959 - 1548 WP_232043823.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
LTK17_RS05655 (LTK17_05655) 1121252..1121518 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
LTK17_RS05660 (LTK17_05660) 1121518..1121769 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LTK17_RS05665 (LTK17_05665) 1121933..1122033 - 101 Protein_1078 hypothetical protein -
LTK17_RS05670 (LTK17_05670) 1122040..1122639 - 600 WP_000162804.1 DsbA family protein -
LTK17_RS05675 (LTK17_05675) 1122658..1123020 - 363 WP_000819843.1 DUF4467 domain-containing protein -
LTK17_RS05680 (LTK17_05680) 1123275..1124525 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
LTK17_RS05685 (LTK17_05685) 1124622..1125353 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
LTK17_RS05690 (LTK17_05690) 1125350..1126069 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T227735 WP_000251928.1 NZ_CP089157:c1121518-1121252 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T227735 NZ_CP123025:c60925-60791 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT227735 WP_000584497.1 NZ_CP089157:c1121769-1121518 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT227735 NZ_CP123025:60970-61030 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References