Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 565228..565408 Replicon chromosome
Accession NZ_CP089157
Organism Staphylococcus aureus strain UNC_SaCF30

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag LTK17_RS02660 Protein ID WP_001801861.1
Coordinates 565228..565323 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 565351..565408 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK17_RS02630 (LTK17_02630) 560372..560998 + 627 WP_000669038.1 hypothetical protein -
LTK17_RS02635 (LTK17_02635) 561039..561383 + 345 WP_000627550.1 DUF3969 family protein -
LTK17_RS02640 (LTK17_02640) 561481..562053 + 573 WP_000414222.1 hypothetical protein -
LTK17_RS02645 (LTK17_02645) 562202..563569 - 1368 WP_001093574.1 FRG domain-containing protein -
LTK17_RS02650 (LTK17_02650) 563569..564138 - 570 WP_000125075.1 ImmA/IrrE family metallo-endopeptidase -
LTK17_RS02655 (LTK17_02655) 564331..564777 - 447 WP_000747804.1 DUF1433 domain-containing protein -
LTK17_RS02660 (LTK17_02660) 565228..565323 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 565351..565408 - 58 - - Antitoxin
LTK17_RS02665 (LTK17_02665) 565446..565547 + 102 WP_001791232.1 hypothetical protein -
LTK17_RS02670 (LTK17_02670) 565722..566165 - 444 WP_001037039.1 DUF1433 domain-containing protein -
LTK17_RS02675 (LTK17_02675) 566165..566608 - 444 WP_000731421.1 DUF1433 domain-containing protein -
LTK17_RS02680 (LTK17_02680) 566608..567050 - 443 Protein_532 DUF1433 domain-containing protein -
LTK17_RS02685 (LTK17_02685) 567575..569995 + 2421 WP_000182553.1 polysaccharide lyase 8 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T227729 WP_001801861.1 NZ_CP089157:565228-565323 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T227729 NZ_CP123024:2719962-2720069 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 58 bp

>AT227729 NZ_CP089157:c565408-565351 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References