Detailed information of TA system TA227726

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1034620..1034804
• Replicon: chromosome
• Accession: NZ_CP089156
• Organism: Staphylococcus aureus strain UNC_SaCF35

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: LTK19_RS05635
• Protein ID: WP_000482647.1
• Coordinates: 1034697..1034804 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1034620..1034680 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LTK19_RS05620 (LTK19_05620)	1030130..1030297	-	168	Protein_1071	hypothetical protein	-
LTK19_RS05625 (LTK19_05625)	1030528..1032261	-	1734	WP_000486505.1	ABC transporter ATP-binding protein	-
LTK19_RS05630 (LTK19_05630)	1032286..1034049	-	1764	WP_001064829.1	ABC transporter ATP-binding protein	-
-	1034620..1034680	+	61	-	-	Antitoxin
LTK19_RS05635 (LTK19_05635)	1034697..1034804	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
LTK19_RS05640 (LTK19_05640)	1034938..1035324	-	387	WP_000779351.1	flippase GtxA	-
LTK19_RS05645 (LTK19_05645)	1035592..1036734	+	1143	WP_001176855.1	glycerate kinase	-
LTK19_RS05650 (LTK19_05650)	1036794..1037453	+	660	WP_000831298.1	membrane protein	-
LTK19_RS05655 (LTK19_05655)	1037635..1038846	+	1212	WP_001191919.1	multidrug effflux MFS transporter	-
LTK19_RS05660 (LTK19_05660)	1038969..1039442	-	474	WP_000456496.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T227726 WP_000482647.1 NZ_CP089156:c1034804-1034697 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T227726 NZ_CP123024:c1869559-1869185 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT227726 NZ_CP089156:1034620-1034680 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin