Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1009318..1009835 Replicon chromosome
Accession NZ_CP089156
Organism Staphylococcus aureus strain UNC_SaCF35

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag LTK19_RS05500 Protein ID WP_000251928.1
Coordinates 1009318..1009584 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag LTK19_RS05505 Protein ID WP_000584497.1
Coordinates 1009584..1009835 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK19_RS05475 (LTK19_05475) 1004526..1005062 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
LTK19_RS05480 (LTK19_05480) 1005530..1006354 - 825 WP_000594640.1 formate/nitrite transporter family protein -
LTK19_RS05485 (LTK19_05485) 1006557..1006739 - 183 WP_000079140.1 hypothetical protein -
LTK19_RS05490 (LTK19_05490) 1006825..1007292 - 468 WP_000153340.1 SRPBCC domain-containing protein -
LTK19_RS05495 (LTK19_05495) 1007478..1009025 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
LTK19_RS05500 (LTK19_05500) 1009318..1009584 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
LTK19_RS05505 (LTK19_05505) 1009584..1009835 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LTK19_RS05510 (LTK19_05510) 1009999..1010099 - 101 Protein_1049 hypothetical protein -
LTK19_RS05515 (LTK19_05515) 1010106..1010705 - 600 WP_000162804.1 DsbA family protein -
LTK19_RS05520 (LTK19_05520) 1010724..1011086 - 363 WP_000819843.1 DUF4467 domain-containing protein -
LTK19_RS05525 (LTK19_05525) 1011341..1012591 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
LTK19_RS05530 (LTK19_05530) 1012688..1013419 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
LTK19_RS05535 (LTK19_05535) 1013416..1014135 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T227725 WP_000251928.1 NZ_CP089156:c1009584-1009318 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T227725 NZ_CP123024:1837778-1838032 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT227725 WP_000584497.1 NZ_CP089156:c1009835-1009584 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT227725 NZ_CP123024:1837530-1837781 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References