Detailed information of TA system TA227724

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-sprA1AS/-
• Location: 746392..746589
• Replicon: chromosome
• Accession: NZ_CP089156
• Organism: Staphylococcus aureus strain UNC_SaCF35

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: -
• Locus tag: LTK19_RS04130
• Protein ID: WP_073392962.1
• Coordinates: 746485..746589 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	746392..746430 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LTK19_RS04105 (LTK19_04105)	741465..741785	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
LTK19_RS04110 (LTK19_04110)	741787..742767	+	981	WP_000019741.1	CDF family zinc efflux transporter CzrB	-
LTK19_RS04115 (LTK19_04115)	743033..744124	+	1092	WP_000495684.1	hypothetical protein	-
LTK19_RS04120 (LTK19_04120)	744412..746067	+	1656	WP_232044001.1	IS1182-like element ISSau3 family transposase	-
LTK19_RS04125 (LTK19_04125)	746372..746446	+	75	Protein_781	hypothetical protein	-
-	746392..746430	+	39	-	-	Antitoxin
LTK19_RS04130 (LTK19_04130)	746485..746589	-	105	WP_073392962.1	hypothetical protein	Toxin
LTK19_RS04135 (LTK19_04135)	747269..747427	+	159	WP_001792784.1	hypothetical protein	-
LTK19_RS04140 (LTK19_04140)	748086..748943	-	858	WP_232044002.1	HAD family hydrolase	-
LTK19_RS04145 (LTK19_04145)	749011..749793	-	783	WP_232044003.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	744412..746067	1655

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3920.80 Da
• Isoelectric Point: 5.5724

>T227724 WP_073392962.1 NZ_CP089156:c746589-746485 [Staphylococcus aureus]
MLLLERTSMSDFEMLMIVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T227724 NZ_CP123024:1837530-1837781 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Nucleotide

• Length: 39 bp

>AT227724 NZ_CP089156:746392-746430 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Antitoxin