Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 511275..511689 | Replicon | chromosome |
| Accession | NZ_CP089156 | ||
| Organism | Staphylococcus aureus strain UNC_SaCF35 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | LTK19_RS02840 | Protein ID | WP_031895065.1 |
| Coordinates | 511438..511689 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LTK19_RS02835 | Protein ID | WP_000028424.1 |
| Coordinates | 511275..511448 (-) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LTK19_RS02785 (LTK19_02785) | 506733..507956 | - | 1224 | WP_001037577.1 | PBSX family phage terminase large subunit | - |
| LTK19_RS02790 (LTK19_02790) | 507949..508443 | - | 495 | WP_000594081.1 | terminase | - |
| LTK19_RS02795 (LTK19_02795) | 508798..509199 | - | 402 | WP_232043987.1 | hypothetical protein | - |
| LTK19_RS02800 (LTK19_02800) | 509200..509373 | - | 174 | WP_025174881.1 | transcriptional activator RinB | - |
| LTK19_RS02805 (LTK19_02805) | 509373..509759 | - | 387 | WP_232043988.1 | DUF1523 family protein | - |
| LTK19_RS02810 (LTK19_02810) | 509749..509985 | - | 237 | WP_000483477.1 | hypothetical protein | - |
| LTK19_RS02815 (LTK19_02815) | 510010..510246 | - | 237 | WP_000195806.1 | DUF1381 domain-containing protein | - |
| LTK19_RS02820 (LTK19_02820) | 510283..510816 | - | 534 | WP_232043989.1 | dUTPase | - |
| LTK19_RS02825 (LTK19_02825) | 510834..510992 | - | 159 | WP_000889681.1 | hypothetical protein | - |
| LTK19_RS02830 (LTK19_02830) | 510993..511274 | - | 282 | WP_000454994.1 | hypothetical protein | - |
| LTK19_RS02835 (LTK19_02835) | 511275..511448 | - | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| LTK19_RS02840 (LTK19_02840) | 511438..511689 | - | 252 | WP_031895065.1 | DUF1024 family protein | Toxin |
| LTK19_RS02845 (LTK19_02845) | 511704..511946 | - | 243 | WP_001562543.1 | SAV1978 family virulence-associated passenger protein | - |
| LTK19_RS02850 (LTK19_02850) | 511950..512306 | - | 357 | WP_000029376.1 | SA1788 family PVL leukocidin-associated protein | - |
| LTK19_RS02855 (LTK19_02855) | 512434..512739 | - | 306 | WP_000101252.1 | hypothetical protein | - |
| LTK19_RS02860 (LTK19_02860) | 512740..512925 | - | 186 | WP_001187243.1 | DUF3113 family protein | - |
| LTK19_RS02865 (LTK19_02865) | 512930..513334 | - | 405 | WP_232043990.1 | DUF1064 domain-containing protein | - |
| LTK19_RS02870 (LTK19_02870) | 513344..513565 | - | 222 | WP_001123688.1 | DUF3269 family protein | - |
| LTK19_RS02875 (LTK19_02875) | 513578..513739 | - | 162 | WP_000237154.1 | hypothetical protein | - |
| LTK19_RS02880 (LTK19_02880) | 513733..514512 | - | 780 | WP_001668921.1 | ATP-binding protein | - |
| LTK19_RS02885 (LTK19_02885) | 514522..515325 | - | 804 | WP_000504982.1 | phage replisome organizer N-terminal domain-containing protein | - |
| LTK19_RS02890 (LTK19_02890) | 515297..516079 | - | 783 | WP_031880075.1 | AP2 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 480556..524708 | 44152 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9469.40 Da Isoelectric Point: 3.7415
>T227721 WP_031895065.1 NZ_CP089156:c511689-511438 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTSQVVYKYEEAQE
NEY
MNNREQIEQSIISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTSQVVYKYEEAQE
NEY
Download Length: 252 bp
>T227721 NZ_CP123024:1045418-1045753 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT227721 WP_000028424.1 NZ_CP089156:c511448-511275 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT227721 NZ_CP123024:1045170-1045418 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|