Detailed information of TA system TA227718

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 396014..396194
• Replicon: chromosome
• Accession: NZ_CP089156
• Organism: Staphylococcus aureus strain UNC_SaCF35

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: LTK19_RS02060
• Protein ID: WP_001801861.1
• Coordinates: 396014..396109 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	396137..396194 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LTK19_RS02030 (LTK19_02030)	391158..391784	+	627	WP_000669038.1	hypothetical protein	-
LTK19_RS02035 (LTK19_02035)	391825..392169	+	345	WP_000627550.1	DUF3969 family protein	-
LTK19_RS02040 (LTK19_02040)	392267..392839	+	573	WP_000414222.1	hypothetical protein	-
LTK19_RS02045 (LTK19_02045)	392988..394355	-	1368	WP_001093574.1	FRG domain-containing protein	-
LTK19_RS02050 (LTK19_02050)	394355..394924	-	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
LTK19_RS02055 (LTK19_02055)	395117..395563	-	447	WP_000747804.1	DUF1433 domain-containing protein	-
LTK19_RS02060 (LTK19_02060)	396014..396109	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	396137..396194	-	58	-	-	Antitoxin
LTK19_RS02065 (LTK19_02065)	396232..396333	+	102	WP_001791232.1	hypothetical protein	-
LTK19_RS02070 (LTK19_02070)	396508..396951	-	444	WP_001037039.1	DUF1433 domain-containing protein	-
LTK19_RS02075 (LTK19_02075)	396951..397394	-	444	WP_000731421.1	DUF1433 domain-containing protein	-
LTK19_RS02080 (LTK19_02080)	397394..397836	-	443	Protein_414	DUF1433 domain-containing protein	-
LTK19_RS02085 (LTK19_02085)	398361..400781	+	2421	WP_000182553.1	polysaccharide lyase 8 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T227718 WP_001801861.1 NZ_CP089156:396014-396109 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T227718 NZ_CP123024:c656635-656171 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT227718 NZ_CP089156:c396194-396137 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin