Detailed information of TA system TA227715

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 61844..62423
• Replicon: chromosome
• Accession: NZ_CP089156
• Organism: Staphylococcus aureus strain UNC_SaCF35

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: LTK19_RS00400
• Protein ID: WP_001025401.1
• Coordinates: 62178..62423 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	61844..62209 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LTK19_RS00360 (LTK19_00360)	58587..59144	-	558	WP_000645048.1	DUF2815 family protein	-
LTK19_RS00365 (LTK19_00365)	59170..60336	-	1167	WP_232043970.1	DUF2800 domain-containing protein	-
LTK19_RS00370 (LTK19_00370)	60333..60695	-	363	WP_049283401.1	hypothetical protein	-
LTK19_RS00375 (LTK19_00375)	60710..61033	-	324	WP_000175000.1	hypothetical protein	-
LTK19_RS00380 (LTK19_00380)	61112..61273	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
LTK19_RS00385 (LTK19_00385)	61286..61549	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
LTK19_RS00390 (LTK19_00390)	61574..61789	-	216	WP_001097552.1	hypothetical protein	-
LTK19_RS00395 (LTK19_00395)	61844..62209	+	366	WP_001128433.1	hypothetical protein	Antitoxin
LTK19_RS00400 (LTK19_00400)	62178..62423	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
LTK19_RS00405 (LTK19_00405)	62490..62870	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
LTK19_RS00410 (LTK19_00410)	62857..63054	-	198	WP_001148860.1	hypothetical protein	-
LTK19_RS00415 (LTK19_00415)	63124..63336	+	213	WP_000362644.1	hypothetical protein	-
LTK19_RS00420 (LTK19_00420)	63377..63526	-	150	WP_000771849.1	hypothetical protein	-
LTK19_RS00425 (LTK19_00425)	63541..63984	-	444	WP_000435357.1	hypothetical protein	-
LTK19_RS00430 (LTK19_00430)	64032..64244	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
LTK19_RS00435 (LTK19_00435)	64396..65127	+	732	WP_000511090.1	XRE family transcriptional regulator	-
LTK19_RS00440 (LTK19_00440)	65198..65380	+	183	WP_000705240.1	hypothetical protein	-
LTK19_RS00445 (LTK19_00445)	65527..65877	-	351	WP_223200492.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	23207..80256	57049

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T227715 WP_001025401.1 NZ_CP089156:c62423-62178 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T227715 NZ_CP123024:c49719-49342 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCATCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Nucleotide

• Length: 366 bp

>AT227715 NZ_CP089156:61844-62209 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin