Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 54813..55236 Replicon chromosome
Accession NZ_CP089156
Organism Staphylococcus aureus strain UNC_SaCF35

Toxin (Protein)


Gene name higB Uniprot ID A0A6B5KJM6
Locus tag LTK19_RS00325 Protein ID WP_001065110.1
Coordinates 54985..55236 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E1X568
Locus tag LTK19_RS00320 Protein ID WP_000028425.1
Coordinates 54813..54995 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK19_RS00280 (LTK19_00280) 50206..50496 - 291 WP_000665205.1 VRR-NUC domain-containing protein -
LTK19_RS00285 (LTK19_00285) 50630..50734 + 105 WP_015978074.1 hypothetical protein -
LTK19_RS00290 (LTK19_00290) 50837..53284 - 2448 WP_049283435.1 virulence-associated E family protein -
LTK19_RS00295 (LTK19_00295) 53337..53537 - 201 WP_000265258.1 DUF1514 family protein -
LTK19_RS00300 (LTK19_00300) 53605..53757 - 153 WP_000595237.1 transcriptional activator RinB -
LTK19_RS00305 (LTK19_00305) 53750..53986 - 237 WP_000483477.1 hypothetical protein -
LTK19_RS00310 (LTK19_00310) 54011..54247 - 237 WP_000195806.1 DUF1381 domain-containing protein -
LTK19_RS00315 (LTK19_00315) 54284..54820 - 537 WP_000185703.1 dUTPase -
LTK19_RS00320 (LTK19_00320) 54813..54995 - 183 WP_000028425.1 hypothetical protein Antitoxin
LTK19_RS00325 (LTK19_00325) 54985..55236 - 252 WP_001065110.1 DUF1024 family protein Toxin
LTK19_RS00330 (LTK19_00330) 55251..55493 - 243 WP_000132193.1 SAV1978 family virulence-associated passenger protein -
LTK19_RS00335 (LTK19_00335) 55508..55708 - 201 WP_000235324.1 hypothetical protein -
LTK19_RS00340 (LTK19_00340) 55711..55968 - 258 WP_000022730.1 DUF3310 domain-containing protein -
LTK19_RS00345 (LTK19_00345) 55968..56369 - 402 WP_000113974.1 PVL family protein -
LTK19_RS00350 (LTK19_00350) 56369..56554 - 186 WP_001164629.1 DUF3113 family protein -
LTK19_RS00355 (LTK19_00355) 56567..58519 - 1953 WP_001802096.1 DNA polymerase -
LTK19_RS00360 (LTK19_00360) 58587..59144 - 558 WP_000645048.1 DUF2815 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 23207..80256 57049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9405.32 Da        Isoelectric Point: 3.8051

>T227714 WP_001065110.1 NZ_CP089156:c55236-54985 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T227714 NZ_CP123019:81817-82197 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTAGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6781.65 Da        Isoelectric Point: 4.4421

>AT227714 WP_000028425.1 NZ_CP089156:c54995-54813 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDGSIISLIDFVIKPIHLIKEAQEND

Download         Length: 183 bp

>AT227714 NZ_CP123019:81596-81817 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B5KJM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1X568

References