Detailed information of TA system TA227712

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2479423..2479607
• Replicon: chromosome
• Accession: NZ_CP089154
• Organism: Staphylococcus aureus strain UNC_SaCF36

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: LTK15_RS12240
• Protein ID: WP_000482647.1
• Coordinates: 2479423..2479530 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2479547..2479607 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LTK15_RS12215	2474787..2475260	+	474	WP_000456491.1	GyrI-like domain-containing protein	-
LTK15_RS12220	2475383..2476594	-	1212	WP_001191975.1	multidrug effflux MFS transporter	-
LTK15_RS12225	2476774..2477433	-	660	WP_000831298.1	membrane protein	-
LTK15_RS12230	2477493..2478635	-	1143	WP_001176860.1	glycerate kinase	-
LTK15_RS12235	2478903..2479289	+	387	WP_000779354.1	flippase GtxA	-
LTK15_RS12240	2479423..2479530	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2479547..2479607	-	61	-	-	Antitoxin
LTK15_RS12245	2479557..2479724	+	168	WP_000301894.1	hypothetical protein	-
LTK15_RS12250	2480102..2481841	+	1740	WP_001064831.1	ABC transporter ATP-binding protein	-
LTK15_RS12255	2481890..2483623	+	1734	WP_000488492.1	ABC transporter ATP-binding protein	-
LTK15_RS12260	2483854..2484021	+	168	WP_031785511.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T227712 WP_000482647.1 NZ_CP089154:2479423-2479530 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T227712 NZ_CP123019:c62778-62473 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTCTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT227712 NZ_CP089154:c2479607-2479547 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin