Detailed information of TA system TA227708

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprA2AS/-
• Location: 197929..198236
• Replicon: chromosome
• Accession: NZ_CP089154
• Organism: Staphylococcus aureus strain UNC_SaCF36

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: LTK15_RS01060
• Protein ID: WP_011447039.1
• Coordinates: 197929..198105 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	198095..198236 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LTK15_RS01040	193164..196949	+	3786	WP_196579352.1	phage tail spike protein	-
LTK15_RS01045	196939..197091	+	153	WP_001153681.1	hypothetical protein	-
LTK15_RS01050	197138..197425	+	288	WP_001040261.1	hypothetical protein	-
LTK15_RS01055	197483..197779	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
LTK15_RS01060	197929..198105	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	198095..198236	-	142	-	-	Antitoxin
LTK15_RS01070	198317..198571	+	255	WP_000611512.1	phage holin	-
LTK15_RS01075	198583..199338	+	756	WP_000861038.1	CHAP domain-containing protein	-
LTK15_RS01080	199529..200020	+	492	WP_000919350.1	staphylokinase	-
LTK15_RS01085	200669..201004	+	336	Protein_202	SH3 domain-containing protein	-
LTK15_RS01090	201099..201548	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
LTK15_RS01095	202231..202581	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
LTK15_RS01100	202634..202894	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / sak / chp / scn	156513..202581	46068

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T227708 WP_011447039.1 NZ_CP089154:197929-198105 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T227708 NZ_CP123017:2916901-2917557 [Escherichia coli]
ATGGCTTATGATTACAGCGCCAGCCTCAACCCGCAAAAAGCTCTGATCTGGCGTATCGTCCATCGGGACAATATCCCGTG
GATTCTGGATAACGGGCTGCACTGCGGCAACAGTCTGGTGCAGGCGGAAAACTGGATCAATATCGGCAACCCGGAGCTGA
TCGGCAAGCGTGCCGGGCATCCGGTACCTGTCGGAACGGGCGGGACACTGCATGACTATGTGCCGTTTTATTTTACCCCC
TTCTCGCCAATGCTGATGAACATCCACAGCGGGCGCGGCGGCATTAAGCAACGCCCCAATGAGGAGATCGTTATTCTGGT
CAGCAACTTGCGAAACGTGGCAGCACACGACGTACCCTTCGTGTTTACCGACAGCCATGCTTACTATAACTGGACCAACT
ACTACACCAGTCTGGATAGTCTGGACCAGATCGACTGGCCCATTTTGCAGGCACGGGACTTTCGCCGCGATCCAGACGAT
CCGGCTAAATTTGAACGCTATCAGGCAGAGGCGCTAATCTGGCAACACTGCCCGATCTCTCTGCTGGATGGGATAATTTG
TTACAGCGAAGAGGTCAGGTTACAATTAGAACAATGGCTGTTTCAGCGTAATCTAACAATGTCCGTTCACACACGGGCTG
GATGGTACTTCTCATGA

Antitoxin

Nucleotide

• Length: 142 bp

>AT227708 NZ_CP089154:c198236-198095 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Structures

Toxin

• PDB: 7NS1

Antitoxin