Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 805129..805822 Replicon chromosome
Accession NZ_CP089142
Organism Escherichia coli strain XD35

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag K0768_RS07275 Protein ID WP_063084548.1
Coordinates 805129..805425 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag K0768_RS07280 Protein ID WP_000650107.1
Coordinates 805427..805822 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0768_RS07240 (800217) 800217..800531 - 315 WP_063084545.1 putative quinol monooxygenase -
K0768_RS07245 (800562) 800562..801143 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
K0768_RS07250 (801462) 801462..801794 + 333 WP_000917684.1 DUF2645 family protein -
K0768_RS07255 (801840) 801840..803189 - 1350 WP_063084546.1 quorum sensing histidine kinase QseC -
K0768_RS07260 (803186) 803186..803845 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
K0768_RS07265 (803997) 803997..804389 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
K0768_RS07270 (804442) 804442..804924 + 483 WP_000183505.1 GyrI-like domain-containing protein -
K0768_RS07275 (805129) 805129..805425 + 297 WP_063084548.1 type II toxin-antitoxin system toxin MqsR Toxin
K0768_RS07280 (805427) 805427..805822 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
K0768_RS07285 (805955) 805955..807562 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
K0768_RS07290 (807700) 807700..809958 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11290.00 Da        Isoelectric Point: 8.0440

>T227673 WP_063084548.1 NZ_CP089142:805129-805425 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELDLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T227673 NZ_CP123013:1045418-1045753 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT227673 WP_000650107.1 NZ_CP089142:805427-805822 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT227673 NZ_CP123013:1045170-1045418 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References