Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4977736..4978238 Replicon chromosome
Accession NZ_CP089065
Organism Pseudomonas aeruginosa strain UNC_PaerCF34

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1C7CBF7
Locus tag LSP20_RS23065 Protein ID WP_023081358.1
Coordinates 4977736..4977990 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1C7C600
Locus tag LSP20_RS23070 Protein ID WP_004350479.1
Coordinates 4977987..4978238 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSP20_RS23045 (LSP20_23055) 4974202..4975065 + 864 WP_034044505.1 integrase domain-containing protein -
LSP20_RS23050 (LSP20_23060) 4975240..4975590 + 351 WP_033862875.1 hypothetical protein -
LSP20_RS23055 (LSP20_23065) 4975605..4977125 + 1521 WP_033862874.1 conjugal transfer protein TraG N-terminal domain-containing protein -
LSP20_RS23060 (LSP20_23070) 4977133..4977519 - 387 WP_033862873.1 DUF3742 family protein -
LSP20_RS23065 (LSP20_23075) 4977736..4977990 - 255 WP_023081358.1 Txe/YoeB family addiction module toxin Toxin
LSP20_RS23070 (LSP20_23080) 4977987..4978238 - 252 WP_004350479.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
LSP20_RS23075 (LSP20_23085) 4978461..4979693 - 1233 Protein_4565 tyrosine-type recombinase/integrase -
LSP20_RS23095 (LSP20_23105) 4980448..4981221 + 774 WP_003090903.1 hypothetical protein -
LSP20_RS23100 (LSP20_23110) 4981283..4981945 + 663 WP_003098798.1 glutathione S-transferase family protein -
LSP20_RS23105 (LSP20_23115) 4981955..4982437 - 483 WP_023517761.1 GAF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4970798..4979693 8895


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10061.50 Da        Isoelectric Point: 8.4789

>T227598 WP_023081358.1 NZ_CP089065:c4977990-4977736 [Pseudomonas aeruginosa]
VKLIWSEQAWDDYLYWQDTDKRMVKKVNELIKDACRTPFEGKGKPEPLRHNLAGFWSRRITAEHRFVYSVTDDALLIAAC
RYHY

Download         Length: 255 bp

>T227598 NZ_CP123000:c2998932-2998513 [Neorhizobium petrolearium]
ATGATCTTGCTGGACACCAACGTTATATCCGAGCCTTGGAAACCGGTTCCTGACGCGGCAGTGATCGACTGGTTGGACGC
CCAAGCTATCGAAACGCTGTTCCTCTCCGCAATAACGATTGCTGAACTTCGCTTCGGGATTGCTGCTATGCCTTCAGGGA
GACGGCAAACTATCCTCCGCGACCGCCTTGAGGGCGAAGTGCTGCCCCACTTTTCCGAGCGCATCCTGCCCTTCGATCTG
GCGACTTCTCAGTTTTATTCGGAACTGATGGCATGCGCTCGAGTATCTGGGAAGGCGATCGGCACAGCTGATGGCTACAT
TGCAGCCTCAGCGGCAGCAAACGGCCTCGCGGTCGCAACTCGCGACACAAGCCCGTTCGCGGCTGCTGGGTTGAAGGTGA
TCAATCCCTGGTCCAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9363.65 Da        Isoelectric Point: 4.5843

>AT227598 WP_004350479.1 NZ_CP089065:c4978238-4977987 [Pseudomonas aeruginosa]
MRTISYTEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEFNALEETAYLLRSPANARRLMDSIDSLKQGQGVERD
LAE

Download         Length: 252 bp

>AT227598 NZ_CP123000:c2999183-2998929 [Neorhizobium petrolearium]
ATGCCGGCAGTCACCATTCGAAACCTTTCTGACGAAACACATCGTGCTCTGCGGCTGCGAGCGGCTCATCATGGCCGAAG
CACCGAGGCCGAGATCCGTGACATTATTGAAGCCGCTGTTCGTCCCCCCGAACGTGTTAAGCTTGGCTCTTTACTGGCGG
CTATTGGTCGTGATGCCGAGCTTTCCGACAGCGACGTTGAGGCCCTGCAGAAAAGTCGCGACAAAACGCCTGCTGAACCG
ATGACCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7CBF7

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C600

References