Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 484624..485209 Replicon chromosome
Accession NZ_CP089051
Organism Acinetobacter ursingii strain RIVM_C010559

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LSO60_RS02340 Protein ID WP_263512813.1
Coordinates 484624..484944 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LSO60_RS02345 Protein ID WP_044436436.1
Coordinates 484937..485209 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSO60_RS02320 (LSO60_02320) 479799..481028 + 1230 WP_263512811.1 MFS transporter -
LSO60_RS02325 (LSO60_02325) 481089..481376 - 288 WP_034698899.1 DUF3817 domain-containing protein -
LSO60_RS02330 (LSO60_02330) 481449..483599 - 2151 WP_263512812.1 YccS family putative transporter -
LSO60_RS02335 (LSO60_02335) 483721..484332 - 612 WP_120371068.1 NAD(P)-dependent oxidoreductase -
LSO60_RS02340 (LSO60_02340) 484624..484944 + 321 WP_263512813.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LSO60_RS02345 (LSO60_02345) 484937..485209 + 273 WP_044436436.1 NadS family protein Antitoxin
LSO60_RS02350 (LSO60_02350) 485304..485558 + 255 WP_044436438.1 CPCC family cysteine-rich protein -
LSO60_RS02355 (LSO60_02355) 485751..486860 - 1110 WP_151722176.1 AI-2E family transporter -
LSO60_RS02360 (LSO60_02360) 487078..487722 - 645 WP_263512814.1 ParA family protein -
LSO60_RS02365 (LSO60_02365) 487904..488371 + 468 WP_004995192.1 Holliday junction resolvase-like protein -
LSO60_RS02370 (LSO60_02370) 488576..489136 + 561 WP_004995190.1 hypothetical protein -
LSO60_RS02375 (LSO60_02375) 489219..489788 - 570 WP_263512815.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12296.15 Da        Isoelectric Point: 8.8733

>T227561 WP_263512813.1 NZ_CP089051:484624-484944 [Acinetobacter ursingii]
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLIQPDRGDLIKNGGGIRKVRCVQGNKGKSSGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKQTAMLRQLVKEQFHG

Download         Length: 321 bp

>T227561 NZ_CP122950:c139083-138802 [Helicobacter pylori]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCTGGGCGTATTAAAGAAAGCGA
TGTTACAAGCATTGTTGATTGCCTAAAAGAACAAAAACCACTCCAACAAAAATATTGCGACCATGCCTTGAGTGGCAATC
TTAAAGGGCTGAGAGAGTGTCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10127.51 Da        Isoelectric Point: 5.8651

>AT227561 WP_044436436.1 NZ_CP089051:484937-485209 [Acinetobacter ursingii]
MDNNLFDDLVASIKEAGAIKREEVKASRVTELELPDIKEVREKTGLSQNEFAARLNISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp

>AT227561 NZ_CP122950:c139390-139076 [Helicobacter pylori]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCATAATTTCTTAAACTCCATTGAAAAACAATT
GCTTAAGGCAGAAGGGGATAAAAATAAGGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACGAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAAGAACCCACACCAAGTTTGTTAAATACGATTGCCTCAAAAGATGACCCAGAA
TACGATGTTTCGTTTGGAGACTTCAATGATTTTCTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References