Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1494112..1494707 Replicon chromosome
Accession NZ_CP089044
Organism Acinetobacter ursingii strain RIVM_C010761

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LSO58_RS07165 Protein ID WP_151833139.1
Coordinates 1494426..1494707 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LSO58_RS07160 Protein ID WP_151833140.1
Coordinates 1494112..1494396 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSO58_RS07115 (LSO58_07090) 1489769..1490203 + 435 WP_263503786.1 phage scaffolding protein -
LSO58_RS07120 (LSO58_07095) 1490206..1490586 + 381 WP_263503787.1 hypothetical protein -
LSO58_RS07125 (LSO58_07100) 1490589..1490957 + 369 WP_263503788.1 glutamate 5-kinase -
LSO58_RS07130 (LSO58_07105) 1490957..1491358 + 402 WP_263503835.1 hypothetical protein -
LSO58_RS07135 (LSO58_07110) 1491333..1491713 + 381 WP_263503836.1 hypothetical protein -
LSO58_RS07140 (LSO58_07115) 1491715..1492113 + 399 WP_262548363.1 phage tail terminator-like protein -
LSO58_RS07145 (LSO58_07120) 1492115..1492288 + 174 WP_262548362.1 hypothetical protein -
LSO58_RS07150 (LSO58_07125) 1492407..1493333 + 927 WP_263503789.1 phage tail tube protein -
LSO58_RS07155 (LSO58_07130) 1493333..1493812 + 480 WP_262548360.1 hypothetical protein -
LSO58_RS07160 (LSO58_07135) 1494112..1494396 - 285 WP_151833140.1 HigA family addiction module antitoxin Antitoxin
LSO58_RS07165 (LSO58_07140) 1494426..1494707 - 282 WP_151833139.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LSO58_RS07170 (LSO58_07145) 1494872..1495144 + 273 WP_228274658.1 hypothetical protein -
LSO58_RS07175 (LSO58_07150) 1495292..1495630 + 339 WP_262548358.1 hypothetical protein -
LSO58_RS07180 (LSO58_07155) 1495716..1495892 + 177 WP_263503790.1 hypothetical protein -
LSO58_RS07185 (LSO58_07160) 1495902..1496228 + 327 WP_263503791.1 DUF4236 domain-containing protein -
LSO58_RS07190 (LSO58_07165) 1496393..1497274 - 882 WP_263503792.1 ORF6N domain-containing protein -
LSO58_RS07195 (LSO58_07170) 1497343..1497498 - 156 WP_151820822.1 Arc family DNA-binding protein -
LSO58_RS07200 (LSO58_07175) 1497605..1497844 + 240 WP_263503793.1 Arc family DNA-binding protein -
LSO58_RS07205 (LSO58_07180) 1497882..1498709 + 828 WP_263503794.1 phosphatidylinositol 4-kinase -
LSO58_RS07210 (LSO58_07185) 1498702..1499526 + 825 WP_263503795.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1418051..1518480 100429


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-91)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10663.04 Da        Isoelectric Point: 9.4224

>T227557 WP_151833139.1 NZ_CP089044:c1494707-1494426 [Acinetobacter ursingii]
MIKSFKHKGLQAFFEDGSTAGIQSAHSKKLRLLLASLNSATSVYDLKTPPNWRLHELKGNLEGHWSLTVNGNWRVTFKFE
DGHAYIVDYQDYH

Download         Length: 282 bp

>T227557 NZ_CP122947:c498077-497793 [Helicobacter pylori]
ATGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACGGAGAACCCTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAATGGACTCAAGGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTC
TAGCACAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTAGAGGACTTTAGCGATTTTACTGAGATTGTGAAATCCTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10399.89 Da        Isoelectric Point: 6.2068

>AT227557 WP_151833140.1 NZ_CP089044:c1494396-1494112 [Acinetobacter ursingii]
MKVMFNAPHPGEILQEYLEGISVTDAARALDVTRTNLSRILNGHTGISADMALRLSEALSTSPELWLNLQVQYDLWIASQ
TKRPTIQHLTPATA

Download         Length: 285 bp

>AT227557 NZ_CP122947:c498447-498058 [Helicobacter pylori]
ATGCCTAACTCTCCCGCCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAATTAGAGCA
AAAGATCAAAAGGATGCAAAATAGAGCTTCTTTTAAAGAAAAAATGGCTAATGAATTGGAAAAAAGGGATCAAAACTTTA
AGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGGTTGTTGTTTGTGG
CACAAGATCCCAAGCATTCAAACGCAACAAGCCATGAGAGATGCGTTAAATGGGGTTAATCTCACTCAAATTGATAGTTT
AGATGATCTTACAAACGAGTTAAAAAGAGAAAATGGTAAAGGTTTTGAAAATGTATGCTTTAGCGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References