Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | symER/SymE(toxin) |
Location | 4781863..4782275 | Replicon | chromosome |
Accession | NZ_CP089036 | ||
Organism | Escherichia coli O157:H7 strain 7386WT |
Toxin (Protein)
Gene name | symE | Uniprot ID | Q8FA88 |
Locus tag | CO544_RS24170 | Protein ID | WP_000132630.1 |
Coordinates | 4781934..4782275 (+) | Length | 114 a.a. |
Antitoxin (RNA)
Gene name | symR | ||
Locus tag | - | ||
Coordinates | 4781863..4781939 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CO544_RS24160 (4778490) | 4778490..4779959 | + | 1470 | WP_001302468.1 | type I restriction-modification system subunit M | - |
CO544_RS24165 (4779959) | 4779959..4781713 | + | 1755 | WP_000110082.1 | restriction endonuclease subunit S | - |
- (4781863) | 4781863..4781939 | - | 77 | NuclAT_14 | - | Antitoxin |
- (4781863) | 4781863..4781939 | - | 77 | NuclAT_14 | - | Antitoxin |
- (4781863) | 4781863..4781939 | - | 77 | NuclAT_14 | - | Antitoxin |
- (4781863) | 4781863..4781939 | - | 77 | NuclAT_14 | - | Antitoxin |
- (4781863) | 4781863..4781939 | - | 77 | NuclAT_15 | - | Antitoxin |
- (4781863) | 4781863..4781939 | - | 77 | NuclAT_15 | - | Antitoxin |
- (4781863) | 4781863..4781939 | - | 77 | NuclAT_15 | - | Antitoxin |
- (4781863) | 4781863..4781939 | - | 77 | NuclAT_15 | - | Antitoxin |
CO544_RS24170 (4781934) | 4781934..4782275 | + | 342 | WP_000132630.1 | endoribonuclease SymE | Toxin |
CO544_RS24175 (4782322) | 4782322..4783485 | - | 1164 | WP_001304006.1 | DUF1524 domain-containing protein | - |
CO544_RS24180 (4783533) | 4783533..4784414 | - | 882 | WP_001304007.1 | DUF262 domain-containing protein | - |
CO544_RS24185 (4784557) | 4784557..4784709 | - | 153 | WP_001418365.1 | hypothetical protein | - |
CO544_RS24190 (4784852) | 4784852..4786264 | + | 1413 | WP_000199295.1 | PLP-dependent aminotransferase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | espX6 | 4774062..4795277 | 21215 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12294.13 Da Isoelectric Point: 8.4982
>T227547 WP_000132630.1 NZ_CP089036:4781934-4782275 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA
Download Length: 342 bp
>T227547 NZ_CP122938:c4371453-4371166 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
Antitoxin
Download Length: 77 bp
>AT227547 NZ_CP089036:c4781939-4781863 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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