Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4781863..4782275 Replicon chromosome
Accession NZ_CP089036
Organism Escherichia coli O157:H7 strain 7386WT

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag CO544_RS24170 Protein ID WP_000132630.1
Coordinates 4781934..4782275 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4781863..4781939 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CO544_RS24160 (4778490) 4778490..4779959 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
CO544_RS24165 (4779959) 4779959..4781713 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- (4781863) 4781863..4781939 - 77 NuclAT_14 - Antitoxin
- (4781863) 4781863..4781939 - 77 NuclAT_14 - Antitoxin
- (4781863) 4781863..4781939 - 77 NuclAT_14 - Antitoxin
- (4781863) 4781863..4781939 - 77 NuclAT_14 - Antitoxin
- (4781863) 4781863..4781939 - 77 NuclAT_15 - Antitoxin
- (4781863) 4781863..4781939 - 77 NuclAT_15 - Antitoxin
- (4781863) 4781863..4781939 - 77 NuclAT_15 - Antitoxin
- (4781863) 4781863..4781939 - 77 NuclAT_15 - Antitoxin
CO544_RS24170 (4781934) 4781934..4782275 + 342 WP_000132630.1 endoribonuclease SymE Toxin
CO544_RS24175 (4782322) 4782322..4783485 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
CO544_RS24180 (4783533) 4783533..4784414 - 882 WP_001304007.1 DUF262 domain-containing protein -
CO544_RS24185 (4784557) 4784557..4784709 - 153 WP_001418365.1 hypothetical protein -
CO544_RS24190 (4784852) 4784852..4786264 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4774062..4795277 21215


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T227547 WP_000132630.1 NZ_CP089036:4781934-4782275 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T227547 NZ_CP122938:c4371453-4371166 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 77 bp

>AT227547 NZ_CP089036:c4781939-4781863 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References