Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1220731..1221368 Replicon chromosome
Accession NC_010513
Organism Xylella fastidiosa M12

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag XFASM12_RS05315 Protein ID WP_004085174.1
Coordinates 1221087..1221368 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag XFASM12_RS05310 Protein ID WP_004087025.1
Coordinates 1220731..1221030 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFASM12_RS05285 1216949..1218541 - 1593 WP_012337641.1 tail fiber domain-containing protein -
XFASM12_RS05290 1218549..1219106 - 558 WP_012337642.1 phage tail protein I -
XFASM12_RS05295 1219099..1219992 - 894 WP_012337643.1 baseplate J/gp47 family protein -
XFASM12_RS05300 1219992..1220330 - 339 WP_004088650.1 GPW/gp25 family protein -
XFASM12_RS05305 1220438..1220719 + 282 WP_004087027.1 XRE family transcriptional regulator -
XFASM12_RS05310 1220731..1221030 + 300 WP_004087025.1 HigA family addiction module antidote protein Antitoxin
XFASM12_RS05315 1221087..1221368 + 282 WP_004085174.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XFASM12_RS05320 1221379..1221654 + 276 WP_012337645.1 HigA family addiction module antidote protein -
XFASM12_RS05325 1221659..1222246 - 588 WP_012337646.1 phage baseplate assembly protein V -
XFASM12_RS05330 1222243..1222785 - 543 WP_012337647.1 hypothetical protein -
XFASM12_RS05335 1222761..1223282 - 522 WP_012337648.1 hypothetical protein -
XFASM12_RS05340 1223279..1223602 - 324 WP_012337649.1 hypothetical protein -
XFASM12_RS05345 1223602..1223862 - 261 WP_012337650.1 hypothetical protein -
XFASM12_RS05350 1223880..1225754 - 1875 WP_012337651.1 phage major capsid protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1210795..1261740 50945


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10610.17 Da        Isoelectric Point: 9.8829

>T22754 WP_004085174.1 NC_010513:1221087-1221368 [Xylella fastidiosa M12]
MIKSFRHKGIQQFFLVGSTAGIQTKHAAKLRIQLTALESAKRPEDMNAPGWKLHPLKGADLKGHWSIWVNGNYRLTFAFE
GEDAILVDYQDYH

Download         Length: 282 bp

>T22754 NC_010513:1221087-1221368 [Xylella fastidiosa M12]
ATGATCAAAAGTTTCCGCCACAAAGGCATTCAACAATTCTTCCTTGTGGGATCAACCGCTGGTATCCAAACCAAACACGC
CGCCAAACTGCGTATCCAGCTCACCGCGTTGGAGAGTGCCAAGCGCCCCGAAGATATGAATGCTCCAGGCTGGAAACTGC
ACCCGCTAAAAGGCGCTGACTTAAAAGGTCATTGGTCCATCTGGGTGAATGGCAACTATCGCCTCACGTTTGCTTTTGAA
GGCGAAGACGCAATCTTGGTCGACTATCAGGATTACCACTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11022.77 Da        Isoelectric Point: 9.0879

>AT22754 WP_004087025.1 NC_010513:1220731-1221030 [Xylella fastidiosa M12]
MTMSKTLPPIHPGEILREEFMVPLGLSSNALAKAIGVTAARINEIVRERRGITAETALRLARYFGTDPQSWLNLEQHYAL
ECAKRDLGDALSRIHPRVA

Download         Length: 300 bp

>AT22754 NC_010513:1220731-1221030 [Xylella fastidiosa M12]
ATGACTATGTCTAAGACACTTCCCCCCATTCACCCAGGAGAAATTCTCCGGGAGGAGTTTATGGTCCCTCTAGGTCTGTC
CAGTAATGCGCTGGCTAAGGCCATTGGGGTGACGGCGGCACGCATCAATGAGATTGTGCGCGAGCGGCGCGGGATCACCG
CAGAGACTGCTTTGCGTCTGGCGCGCTACTTCGGTACCGATCCGCAAAGCTGGCTGAATTTGGAACAGCACTATGCGTTG
GAATGTGCCAAACGTGATCTTGGAGATGCGCTGTCACGGATTCATCCGCGAGTGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References