Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ldrD-sokW/Ldr(toxin) |
| Location | 277101..277322 | Replicon | chromosome |
| Accession | NZ_CP089036 | ||
| Organism | Escherichia coli O157:H7 strain 7386WT | ||
Toxin (Protein)
| Gene name | ldrD | Uniprot ID | S1NWX0 |
| Locus tag | CO544_RS01345 | Protein ID | WP_001295224.1 |
| Coordinates | 277215..277322 (+) | Length | 36 a.a. |
Antitoxin (RNA)
| Gene name | sokW | ||
| Locus tag | - | ||
| Coordinates | 277101..277166 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CO544_RS01325 (272541) | 272541..273443 | + | 903 | WP_000084677.1 | dipeptide ABC transporter permease DppC | - |
| CO544_RS01330 (273454) | 273454..274437 | + | 984 | WP_001196486.1 | dipeptide ABC transporter ATP-binding protein | - |
| CO544_RS01335 (274434) | 274434..275438 | + | 1005 | WP_000107027.1 | dipeptide ABC transporter ATP-binding subunit DppF | - |
| CO544_RS01340 (275468) | 275468..276739 | - | 1272 | WP_001301684.1 | aromatic amino acid transport family protein | - |
| - (277101) | 277101..277166 | - | 66 | NuclAT_16 | - | Antitoxin |
| - (277101) | 277101..277166 | - | 66 | NuclAT_16 | - | Antitoxin |
| - (277101) | 277101..277166 | - | 66 | NuclAT_16 | - | Antitoxin |
| - (277101) | 277101..277166 | - | 66 | NuclAT_16 | - | Antitoxin |
| - (277101) | 277101..277166 | - | 66 | NuclAT_21 | - | Antitoxin |
| - (277101) | 277101..277166 | - | 66 | NuclAT_21 | - | Antitoxin |
| - (277101) | 277101..277166 | - | 66 | NuclAT_21 | - | Antitoxin |
| - (277101) | 277101..277166 | - | 66 | NuclAT_21 | - | Antitoxin |
| CO544_RS01345 (277215) | 277215..277322 | + | 108 | WP_001295224.1 | type I toxin-antitoxin system toxin Ldr family protein | Toxin |
| CO544_RS01350 (277409) | 277409..279088 | - | 1680 | WP_000191596.1 | cellulose biosynthesis protein BcsG | - |
| CO544_RS01355 (279085) | 279085..279276 | - | 192 | WP_000988308.1 | cellulose biosynthesis protein BcsF | - |
| CO544_RS01360 (279273) | 279273..280844 | - | 1572 | WP_001204920.1 | cellulose biosynthesis c-di-GMP-binding protein BcsE | - |
| CO544_RS01365 (281117) | 281117..281305 | + | 189 | WP_001063316.1 | cellulose biosynthesis protein BcsR | - |
| CO544_RS01370 (281317) | 281317..282069 | + | 753 | Protein_273 | cellulose biosynthesis protein BcsQ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 36 a.a. Molecular weight: 3882.70 Da Isoelectric Point: 9.0157
>T227519 WP_001295224.1 NZ_CP089036:277215-277322 [Escherichia coli O157:H7]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK
Download Length: 108 bp
>T227519 NZ_CP122929:c2448250-2448074 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 66 bp
>AT227519 NZ_CP089036:c277166-277101 [Escherichia coli O157:H7]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
