Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4965219..4965631 Replicon chromosome
Accession NZ_CP089034
Organism Escherichia coli O157:H7 strain 6535NalR

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag LSI70_RS25365 Protein ID WP_000132630.1
Coordinates 4965290..4965631 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4965219..4965295 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSI70_RS25355 (4961846) 4961846..4963315 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
LSI70_RS25360 (4963315) 4963315..4965069 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- (4965219) 4965219..4965295 - 77 NuclAT_15 - Antitoxin
- (4965219) 4965219..4965295 - 77 NuclAT_15 - Antitoxin
- (4965219) 4965219..4965295 - 77 NuclAT_15 - Antitoxin
- (4965219) 4965219..4965295 - 77 NuclAT_15 - Antitoxin
- (4965219) 4965219..4965295 - 77 NuclAT_16 - Antitoxin
- (4965219) 4965219..4965295 - 77 NuclAT_16 - Antitoxin
- (4965219) 4965219..4965295 - 77 NuclAT_16 - Antitoxin
- (4965219) 4965219..4965295 - 77 NuclAT_16 - Antitoxin
LSI70_RS25365 (4965290) 4965290..4965631 + 342 WP_000132630.1 endoribonuclease SymE Toxin
LSI70_RS25370 (4965678) 4965678..4966841 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
LSI70_RS25375 (4966889) 4966889..4967770 - 882 WP_001304007.1 DUF262 domain-containing protein -
LSI70_RS25380 (4967913) 4967913..4968065 - 153 WP_001418365.1 hypothetical protein -
LSI70_RS25385 (4968208) 4968208..4969620 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4957418..4978645 21227


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T227513 WP_000132630.1 NZ_CP089034:4965290-4965631 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T227513 NZ_CP122929:1828654-1828905 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 77 bp

>AT227513 NZ_CP089034:c4965295-4965219 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References